195733-43-8
(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
CAS: 195733-43-8
Molecular Formula: C29H38N2O6.HCl
195733-43-8 - Names and Identifiers
195733-43-8 - Physico-chemical Properties
| Molecular Formula | C29H38N2O6.HCl |
| Molar Mass | 547.08 |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| In vitro study | Atrasentan hydrochloride (ABT-627 hydrochloride) (0-50 μM) significantly inhibits LNCaP and C4-2b prostate cancer cell growth. Atrasentan profoundly induces several CYPs and drug transporters (e.g. 12-fold induction of CYP3A4 at 50 μM). It is a moderate P-gp inhibitor (IC 50 in P388/dx cells=15.1±1.6 μM) and a weak BCRP inhibitor (IC 50 in MDCKII-BCRP cells=59.8±11 μM). |
| In vivo study | Atrasentan hydrochloride (ABT-627 hydrochloride) (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats. Aatrasentan (ABT-627, 10 mg/kg, i.p.) inhibits the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model. |
195733-43-8 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.828 ml | 9.139 ml | 18.279 ml |
| 5 mM | 0.366 ml | 1.828 ml | 3.656 ml |
| 10 mM | 0.183 ml | 0.914 ml | 1.828 ml |
| 5 mM | 0.037 ml | 0.183 ml | 0.366 ml |
Last Update：2024-01-02 23:10:35
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Product Name: ABT-627 hydrochloride; (+)-A 127722 hydrochloride; A-147627 hydrochloride Visit Supplier Webpage Request for quotationCAS: 195733-43-8
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Product Name: (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride Visit Supplier Webpage Request for quotationCAS: 195733-43-8
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View History
195733-43-8
1932154-34-1
12220-51-8
637031-88-0
142-83-6
1674-99-3
1-Chlortetradecan
2-Toluenethiol
58336-35-9
148332-36-9
1932154-34-1
12220-51-8
637031-88-0
142-83-6
1674-99-3
1-Chlortetradecan
2-Toluenethiol
58336-35-9
148332-36-9