197250-15-0
GAP 26
CAS: 197250-15-0
Molecular Formula: C70H107N19O19S
197250-15-0 - Names and Identifiers
197250-15-0 - Physico-chemical Properties
| Molecular Formula | C70H107N19O19S |
| Molar Mass | 1550.78 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Water Solubility | Soluble to 2 mg/ml in water |
| Solubility | H2O : 50 mg/mL (32.24 mM; Need ultrasonic) |
| pKa | 3.31±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Use | Gap 26 is a connexin (connexin) mimetic peptide consisting of residues 63-75 of the first extracellular loop of connexin connexin 43 (gap junction blocker) and containing the SHVR amino acid motif. |
| In vitro study | Gap 26 (0.25 mg/mL, 30 min) reduces the wave size in the three cell lines (RBE4, SV-ARBEC and ECV304). Gap 26 (0.25 mg/mL, 30 min) completely abolishes the InsP3-triggered ATP response and reduced the ATP release to below the control level, indicating that the basal ATP release is also affected. Gap 26 does indeed significantly inhibit our InsP3-triggered intercellular calcium waves, but it did not have any effect on dye coupling through junctional channels as evidenced by the FRAP experiments, despite the fact that connexin 43 was present in the cell lines used. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC 50 of 28.4 ± 3.4 μM. |
197250-15-0 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.645 ml | 3.224 ml | 6.448 ml |
| 5 mM | 0.129 ml | 0.645 ml | 1.29 ml |
| 10 mM | 0.064 ml | 0.322 ml | 0.645 ml |
| 5 mM | 0.013 ml | 0.064 ml | 0.129 ml |
Last Update：2024-01-02 23:10:35
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