198545-72-1
(R)-N-FMOC-3-Fluorophenylalanine
CAS: 198545-72-1
Molecular Formula: C24H20FNO4
198545-72-1 - Names and Identifiers
| Name | (R)-N-FMOC-3-Fluorophenylalanine |
| Synonyms | FMOC-D-PHE(3-F)-OH FMOC-D-3-Fluorophe Fmoc-D-3-Fluorophe FMOC-M-FLUORO-D-PHE-OH Fmoc-D-3-Fluorophenylalanine FMOC-M-FLUORO-D-PHENYLALANINE Fmoc-3-Fluoro-D-phenylalanine (R)-N-FMOC-3-Fluorophenylalanine (9H-Fluoren-9-yl)MethOxy]Carbonyl D-Phe(3-F)-OH (R)-2-Fmoc-amino-3-(3-fluorophenyl)propionic acid FMOC-(R)-2-AMINO-3-(3'-FLUOROPHENYL)PROPANOIC ACID (2R)-2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-(3-fluorophenyl)propanoate |
| CAS | 198545-72-1 |
| InChI | InChI=1/C24H20FNO4/c25-16-7-5-6-15(12-16)13-22(23(27)28)26-24(29)30-14-21-19-10-3-1-8-17(19)18-9-2-4-11-20(18)21/h1-12,21-22H,13-14H2,(H,26,29)(H,27,28)/t22-/m1/s1 |
198545-72-1 - Physico-chemical Properties
| Molecular Formula | C24H20FNO4 |
| Molar Mass | 405.42 |
| Density | 1.2642 (estimate) |
| Melting Point | 153.5 °C |
| Boling Point | 618.1±55.0 °C(Predicted) |
| Specific Rotation(α) | 39 º (c=1,DMF) |
| Flash Point | 327.6°C |
| Vapor Presure | 3.89E-16mmHg at 25°C |
| pKa | 3.70±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.622 |
198545-72-1 - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29223900 |
| Hazard Note | Harmful |
| Hazard Class | IRRITANT |
198545-72-1 - Introduction
(R)-N-FMOC-3-Fluorophenylalanine(Fmoc-D-3-fluorophenylalanine) is an important organic synthetic intermediate commonly used in peptide synthesis and drug discovery. The following is a description of its nature, use, formulation and safety information:
Nature:
(R)-N-FMOC-3-Fluorophenylalanine is a colorless to light yellow solid with high solubility. It is a chiral molecule consisting of D-3-fluorophenylalanine and a Fmoc protecting group. It is stable under acidic conditions, but can be deprotected under basic conditions.
Use:
(R)-N-FMOC-3-Fluorophenylalanine is widely used in the synthesis of peptides and proteins. As a substitute for amino acids, it can be introduced into the peptide chain and subjected to deprotection reactions during subsequent chemical modifications. Due to its fluorine atom content,(R)-N-FMOC-3-Fluorophenylalanine are also commonly used in drug development to alter the properties of drug molecules and enhance their biological activity.
Method:
(R)-The preparation of N-FMOC-3-Fluorophenylalanine is generally achieved by chemical synthesis. First, D-3-fluorophenylalanine is reacted with Fmoc-Cl to form (R)-N-FMOC-3-Fluorophenylalanine. The synthesized product can be purified and crystallized to obtain a higher purity product.
Safety Information:
(R)-N-FMOC-3-Fluorophenylalanine are generally less toxic and dangerous when properly operated. However, when used in the laboratory, relevant operating procedures and safety measures should still be observed, such as wearing chemical protective gloves, goggles and laboratory coats. Should be stored in a dry, cool place, away from fire and flammable substances.
Nature:
(R)-N-FMOC-3-Fluorophenylalanine is a colorless to light yellow solid with high solubility. It is a chiral molecule consisting of D-3-fluorophenylalanine and a Fmoc protecting group. It is stable under acidic conditions, but can be deprotected under basic conditions.
Use:
(R)-N-FMOC-3-Fluorophenylalanine is widely used in the synthesis of peptides and proteins. As a substitute for amino acids, it can be introduced into the peptide chain and subjected to deprotection reactions during subsequent chemical modifications. Due to its fluorine atom content,(R)-N-FMOC-3-Fluorophenylalanine are also commonly used in drug development to alter the properties of drug molecules and enhance their biological activity.
Method:
(R)-The preparation of N-FMOC-3-Fluorophenylalanine is generally achieved by chemical synthesis. First, D-3-fluorophenylalanine is reacted with Fmoc-Cl to form (R)-N-FMOC-3-Fluorophenylalanine. The synthesized product can be purified and crystallized to obtain a higher purity product.
Safety Information:
(R)-N-FMOC-3-Fluorophenylalanine are generally less toxic and dangerous when properly operated. However, when used in the laboratory, relevant operating procedures and safety measures should still be observed, such as wearing chemical protective gloves, goggles and laboratory coats. Should be stored in a dry, cool place, away from fire and flammable substances.
Last Update：2024-04-09 21:01:54
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