199113-98-9
Balaglitazone
CAS: 199113-98-9
Molecular Formula: C20H17N3O4S
199113-98-9 - Names and Identifiers
199113-98-9 - Physico-chemical Properties
| Molecular Formula | C20H17N3O4S |
| Molar Mass | 395.43 |
| Density | 1.45±0.1 g/cm3(Predicted) |
| pKa | 6.33±0.50(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | Balaglitazone is a selective partial PPARγ agonist with an EC 50 of 1.351 μM. Balaglitazone (5-100 μM) has equal cytotoxicity towards K562 and K562/DOX cells. Balaglitazone decreases doxorubicin cytotoxicity in K562 and K562/DOX cells, with IC 50 s of 0.117 μM and 0.53 μM, respectively. Balaglitazone reverses multidrug resistance (MDR) in K562/DOX cells. Balaglitazone (25 µM) increases Rh123 accumulation in K562/DOX cells, but does not increases MFI in K562 cells. Balaglitazone downregulates P-gp expression in K562/DOX cells, and such effects are via upregulation of PTEN in K562/DOX cells, and be abolished by PTEN inhibition. |
| In vivo study | Balaglitazone (3 mg/kg, p.o.) shows antihyperglycaemic activity in fully diabetic and insulin resistant db/db mice, and is more potent than the full PPARγ agonist rosiglitazone. Balaglitazone (10 mg/kg, p.o.) suppresses overall glucose, decreases insulin levels, and increases bodyweight in male diet-induced obese rats, and such effects are equal to that of 30 mg/kg pioglitazone. |
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Multiple SpecificationsSpot supply
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View History
199113-98-9
202650-88-2
1145-80-8
4481-62-3
513-81-5
1979-96-0
β-Naphthoxyacetic acid
iso-Butyraldehyd
依地酸二钠
c-10aldehyde
202650-88-2
1145-80-8
4481-62-3
513-81-5
1979-96-0
β-Naphthoxyacetic acid
iso-Butyraldehyd
依地酸二钠
c-10aldehyde