Molecular Formula | C10H20N2O2 |
Molar Mass | 200.28 |
Density | 1.03 |
Boling Point | 269 ºC |
Flash Point | 117 ºC |
pKa | 10.02±0.20(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
MDL | MFCD09752961 |
UN IDs | UN2735 |
Application | (R)-3-(methylamino) pyrrolidine -1-carboxylic acid tert-butyl ester can be used as an intermediate in organic synthesis and pharmaceutical intermediates, mainly used in laboratory research and development process and chemical generation process. |
preparation | (R)-3-(methylamino) pyrrolidine carboxylic acid dissolved in of an aqueous solution of sodium hydroxide, add 200ml of tetrahydrofuran and 250g of di-tert-butyl dicarbonate sequentially, control the pH value to 8-9, react for 12h, extract twice with ethyl acetate, 500ml each time; Then acidify the aqueous phase with HCI to pH value of 1-2, the product was extracted three times with 200ml of ethyl acetate each time; The ester layers were combined and washed twice with ml of saturated brine each time. Dry over anhydrous sodium sulfate for 12h, filter, concentrate the crystals, and dry at 40-50 °c to give tert-butyl (R)-3-(methylamino) pyrrolidine carboxylate. |