2,6-Pyridinedimethanol
2,6-Pyridinedimethanol
CAS: 1195-59-1
Molecular Formula: C7H9NO2
2,6-Pyridinedimethanol - Names and Identifiers
| Name | 2,6-Pyridinedimethanol |
| Synonyms | 2,6-PYRIDINETHANOL 2,6-Pyridinedimethan 2,6-Pyridyldicarbinol LABOTEST-BB LT00233124 2,6-Pyridinedimethanol 2,6-PYRIDINEMETHANOL BIS pyridine-2,6-diyldimethanol 2,6-Dihydroxymethyl Pyridine 2,6-Bis(hydroxymethyl)pyridine (6-Hydroxymethyl-pyridin-2-yl)-methanol |
| CAS | 1195-59-1 |
| EINECS | 214-803-0 |
| InChI | InChI=1/C7H9NO2/c9-4-6-2-1-3-7(5-10)8-6/h1-3,9-10H,4-5H2 |
| InChIKey | WWFMINHWJYHXHF-UHFFFAOYSA-N |
2,6-Pyridinedimethanol - Physico-chemical Properties
| Molecular Formula | C7H9NO2 |
| Molar Mass | 139.15 |
| Density | 1.1997 (rough estimate) |
| Melting Point | 112-114 °C (lit.) |
| Boling Point | 185°C 15mm |
| Flash Point | 185°C/15mm |
| Water Solubility | Soluble in water. |
| Vapor Presure | 0.000574mmHg at 25°C |
| Appearance | White to light yellow powder |
| Color | Light yellow to beige |
| BRN | 116016 |
| pKa | 13.03±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.4800 (estimate) |
| MDL | MFCD00006351 |
| Use | Ligand used in the synthesis of a variety of metal complexes and catalysts. |
2,6-Pyridinedimethanol - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 23 |
| HS Code | 29333999 |
| Hazard Note | Irritant |
2,6-Pyridinedimethanol - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Introduction | 2,6-bisubstituted pyridine is an important organic synthesis intermediate, especially 2,6-pyridine dimethyl alcohol has strong applicability. Hydroxyl can be derived into aldehyde groups, halogenated hydrocarbons, amino groups and many other functional groups, and then synthesize other important compounds. And because it is the substitution of 2 and 6 positions, it can also generate macrocyclic compounds, which are widely used in synthesis and have high research value. |
| preparation | (1) synthesis of 2,6-pyridinedicarboxylic acid: in a 2L flask equipped with a stirrer and a reflux condenser tube, 800mL of water, 53.5 gKMnO4,16.7 g2, 6-dimethylpyridine, heat to reflux, and add another 53.5gKMnO4 and 200mL of water when the color of KMnO4 fades, continue to reflux until the color completely fades (about 2 hours), cool, filter out MnO2, wash the filtered insoluble matter in 500mL of hot water, filter, merge the filtrate, concentrate the filtrate to 200-300mL, filter, then acidify with concentrated HCl, cool, precipitate, filter, and dry to obtain 2, 6-pyridinedicarboxylic acid. Yield: 80%,m.p.220 ℃, consistent with literature. (2) Synthesis of 2, 6-pyridinedicarboxylic acid: 8.8g(0.05mol) and 200mLTHF of 2, 6-pyridinedicarboxylic acid were added into a 500mL three-mouth bottle, cooled to -5 degrees Celsius in an ice salt bath, and 3.8g(0.1mol)NaBH4 was added in batches under stirring. After adding, react for half an hour, and no more gas is generated. Dissolve 0.05mol of iodine in 80mLTHF, drip into it, remove the ice bath after dropping, naturally raise the temperature to room temperature, and stop the reaction after 1.5 hours. Add 3mol/L hydrochloric acid to adjust pH to neutral, filter to remove solid, spin dry solution, shake extraction with ethyl acetate, dry anhydrous magnesium sulfate after drying and spin steaming to obtain 5g of white crystal with 72% yield. |
| use | intermediate of drug xuemaining. Ligands are used to synthesize various metal complexes or catalysts. |
| production method | 2, 6-dichloromethylpyridine is hydrolyzed. |
Last Update：2024-04-09 02:00:06
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View History
2,6-Pyridinedimethanol
Methacrylic acid, furfuryl ester
5-Methoxypyridine-3-carboxaldehyde
N-Benzyl-3-piperidinone
5-chlorothiophene-2-carboxylate
Methacrylic acid, furfuryl ester
5-Methoxypyridine-3-carboxaldehyde
N-Benzyl-3-piperidinone
5-chlorothiophene-2-carboxylate