2-Chloroflumethasone
2-Chloroflumethasone
CAS: 50629-82-8
Molecular Formula: C22H27ClF2O5
2-Chloroflumethasone - Names and Identifiers
| Name | 2-Chloroflumethasone |
| Synonyms | Sicorten HALOMETASONE Halometasone Halomethasone HALOMETASONE HYDRATE 2-Chloroflumethasone 2-chloroflumethasone HALOMETASONE MONOHYDRATE 2-chlor-6a,9-difluor-11b,17,21-trihydroxy-16a-methyl-1,4-pregnadien-3,20-dion (6alpha,11beta,16alpha)-2-chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione (6alpha,11beta,14xi,16alpha)-2-chloro-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione |
| CAS | 50629-82-8 |
| EINECS | 256-664-9 |
| InChI | InChI=1/C22H27ClF2O5/c1-10-4-11-12-5-15(24)13-6-16(27)14(23)7-19(13,2)21(12,25)17(28)8-20(11,3)22(10,30)18(29)9-26/h6-7,10-12,15,17,26,28,30H,4-5,8-9H2,1-3H3/t10-,11+,12+,15+,17+,19+,20+,21+,22+/m1/s1 |
2-Chloroflumethasone - Physico-chemical Properties
| Molecular Formula | C22H27ClF2O5 |
| Molar Mass | 444.9 |
| Density | 1.42±0.1 g/cm3(Predicted) |
| Melting Point | 220-222° (dec) |
| Boling Point | 600.5±55.0 °C(Predicted) |
| Flash Point | 316.994°C |
| Solubility | Acetone (Sparingly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 11.93±0.70(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 1.586 |
| Physical and Chemical Properties | Melting point 220~222 ℃ (decomposition). |
2-Chloroflumethasone - Reference Information
| introduction | halometasone belongs to hormone drugs. it is a glucocorticoid hormone, and its main functions are anti-allergy, vasoconstriction, anti-proliferation and anti-inflammatory. It is often used to treat various non-infectious dermatitis, such as atopic dermatitis, seborrheic dermatitis, contact dermatitis, psoriasis vulgaris, localized neurodermatitis, coin dermatitis, etc. |
| side effects | use of halometasone occasionally causes irritant symptoms at the medication site, such as burning sensation and itching pain. Rare: Dry skin, erythema, skin atrophy, folliculitis, acne or pustules. If severe irritation or allergic symptoms have occurred, treatment should be terminated. |
| chemical properties | melting point 220~222 ℃ (decomposition). |
| use | topical adrenocortical hormone drugs have significant and rapid anti-inflammatory, anti-allergic, anti-pruritic, anti-exudation and anti-proliferative effects. Suitable for eczema skin diseases and all kinds of mild eczema and subacute dermatitis. Indications: It is used for skin diseases that respond to external adrenal cortex hormones, such as acute or chronic eczema diseases and common psoriasis, which have certain curative effects. |
| production method | compound (I) first reacts with chlorine to add the double bonds at the 1 and 2 positions, and then under the action of pyridine, hydrogen chloride is removed and double bonds are re-formed at the 1 and 2 positions; then hydrolyzed to obtain halometasone. |
Last Update：2024-04-09 21:04:16
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