2-Fluoro-3-iodo-5-methylpyridine
2-Fluoro-3-iodo-5-methylpyridine
CAS: 153034-78-7
Molecular Formula: C6H5FIN
2-Fluoro-3-iodo-5-methylpyridine - Names and Identifiers
2-Fluoro-3-iodo-5-methylpyridine - Physico-chemical Properties
| Molecular Formula | C6H5FIN |
| Molar Mass | 237.01 |
| Density | 1.892±0.06 g/cm3(Predicted) |
| Melting Point | 38-42°C |
| Boling Point | 252.5±35.0 °C(Predicted) |
| Flash Point | >110℃ |
| pKa | -2.16±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| MDL | MFCD03095303 |
2-Fluoro-3-iodo-5-methylpyridine - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes R41 - Risk of serious damage to eyes R22 - Harmful if swallowed |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
2-Fluoro-3-iodo-5-methylpyridine - Introduction
It is an organic compound with the chemical formula C6H4FNI. The following is a description of some of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless to yellowish crystal or powder.
-Solubility: It is soluble in organic solvents such as chloroform, dimethyl sulfoxide and ethanol, and insoluble in water.
-Melting point: Its melting point range is about 75-80°C.
Use:
-is an important organic synthesis intermediate that can be used to synthesize other compounds.
-It can be used as a drug synthesis intermediate for the synthesis of some biologically active compounds.
Method: The preparation of
is generally carried out by the following steps:
1. Taking pyridine and iodine, adding sodium hydroxide aqueous solution for iodination reaction.
2. Sodium fluoride is added to a solution of pyridine iodide to carry out a fluorination reaction.
3. Filter the product and undergo appropriate purification steps (such as crystallization) to obtain the target product.
Safety Information:
-has a certain toxicity, should comply with the safety procedures.
-In the process of use, pay attention to avoid skin contact and inhalation, wear protective gloves, protective glasses and protective masks and other personal protective equipment.
-Abnormal skin contact or inhalation of the substance may cause irritation, allergies and other adverse reactions, please properly dispose of waste items, in accordance with relevant laws and regulations for disposal.
-Read and follow the relevant safety data sheets and operating instructions before use. If you have any questions or discomfort, please consult a professional in time.
Nature:
-Appearance: Colorless to yellowish crystal or powder.
-Solubility: It is soluble in organic solvents such as chloroform, dimethyl sulfoxide and ethanol, and insoluble in water.
-Melting point: Its melting point range is about 75-80°C.
Use:
-is an important organic synthesis intermediate that can be used to synthesize other compounds.
-It can be used as a drug synthesis intermediate for the synthesis of some biologically active compounds.
Method: The preparation of
is generally carried out by the following steps:
1. Taking pyridine and iodine, adding sodium hydroxide aqueous solution for iodination reaction.
2. Sodium fluoride is added to a solution of pyridine iodide to carry out a fluorination reaction.
3. Filter the product and undergo appropriate purification steps (such as crystallization) to obtain the target product.
Safety Information:
-has a certain toxicity, should comply with the safety procedures.
-In the process of use, pay attention to avoid skin contact and inhalation, wear protective gloves, protective glasses and protective masks and other personal protective equipment.
-Abnormal skin contact or inhalation of the substance may cause irritation, allergies and other adverse reactions, please properly dispose of waste items, in accordance with relevant laws and regulations for disposal.
-Read and follow the relevant safety data sheets and operating instructions before use. If you have any questions or discomfort, please consult a professional in time.
Last Update：2024-04-09 02:00:42
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