2-Hydroxymethylmorpholine
2-Hydroxymethylmorpholine
CAS: 103003-01-6
Molecular Formula: C5H11NO2
2-Hydroxymethylmorpholine - Names and Identifiers
| Name | 2-Hydroxymethylmorpholine |
| Synonyms | 2-MORPHOLINEMETHANOL MORPHOLIN-2-YL-METHANOL -Hydroxymethylmorpholine 2-Hydroxymethylmorpholine 2-HYDROXYMETHYLMORPHOLINE Morpholin-2-ylMethanol-HCl |
| CAS | 103003-01-6 |
| InChI | InChI=1/C5H11NO2/c7-4-5-3-6-1-2-8-5/h5-7H,1-4H2 |
2-Hydroxymethylmorpholine - Physico-chemical Properties
| Molecular Formula | C5H11NO2 |
| Molar Mass | 117.15 |
| Density | 1.045±0.06 g/cm3(Predicted) |
| Boling Point | 220.1±15.0 °C(Predicted) |
| Flash Point | 86.9°C |
| Vapor Presure | 0.024mmHg at 25°C |
| pKa | 14.36±0.10(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.441 |
2-Hydroxymethylmorpholine - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
2-Hydroxymethylmorpholine - Introduction
2-Hydroxymethylmorpholine (2-Hydroxymethylmorpholine) is an organic compound with the chemical formula C6H13NO2. The following is a description of its nature, use, preparation and safety information:
Nature:
2-hydroxymethyl morpholine is a colorless to pale yellow liquid, with amine-like amino properties and alcohol-like hydrophilic properties. It is easily soluble in water and most organic solvents at room temperature.
Use:
2-Hydroxymethyl morpholine is widely used in organic synthesis. It is an organic base that can be used as a catalyst or a neutralizing agent for reactions. It is commonly used in reactions between sulfonic acids and amines, such as de-sulfonation reactions and anhydride formation reactions. In addition, it can also be used as surfactants, plastic plasticizers, solvents and pharmaceutical intermediates.
Preparation Method:
2-hydroxymethyl morpholine can be obtained by reacting morpholine with formaldehyde. The reaction is usually carried out under basic conditions, and the reaction temperature and time will affect the yield and purity.
Safety Information:
2-Hydroxymethyl morpholine has high safety, but the following information still needs to be paid attention:
-May be irritating to eyes, skin and respiratory tract, wear appropriate protective measures when in contact.
-Avoid prolonged and excessive exposure. Good laboratory safety practices should be observed during operation.
-Avoid direct sunlight and keep away from high temperature and fire sources during storage.
-Waste should be disposed of in accordance with local regulations to avoid direct discharge into the environment.
Please note that when using any chemical, it should be evaluated on a case-by-case basis and operated in accordance with correct laboratory operations and safety procedures.
Nature:
2-hydroxymethyl morpholine is a colorless to pale yellow liquid, with amine-like amino properties and alcohol-like hydrophilic properties. It is easily soluble in water and most organic solvents at room temperature.
Use:
2-Hydroxymethyl morpholine is widely used in organic synthesis. It is an organic base that can be used as a catalyst or a neutralizing agent for reactions. It is commonly used in reactions between sulfonic acids and amines, such as de-sulfonation reactions and anhydride formation reactions. In addition, it can also be used as surfactants, plastic plasticizers, solvents and pharmaceutical intermediates.
Preparation Method:
2-hydroxymethyl morpholine can be obtained by reacting morpholine with formaldehyde. The reaction is usually carried out under basic conditions, and the reaction temperature and time will affect the yield and purity.
Safety Information:
2-Hydroxymethyl morpholine has high safety, but the following information still needs to be paid attention:
-May be irritating to eyes, skin and respiratory tract, wear appropriate protective measures when in contact.
-Avoid prolonged and excessive exposure. Good laboratory safety practices should be observed during operation.
-Avoid direct sunlight and keep away from high temperature and fire sources during storage.
-Waste should be disposed of in accordance with local regulations to avoid direct discharge into the environment.
Please note that when using any chemical, it should be evaluated on a case-by-case basis and operated in accordance with correct laboratory operations and safety procedures.
Last Update：2024-04-09 15:17:50
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