2-Trichloromethyl-4(3H)-quinazolinone

2-Trichloromethyl-4(3H)-quinazolinone - Names and Identifiers

Name	2-Trichloromethyl-4(3H)-quinazolinone
Synonyms	2-Trichloromethyl-4(3H)-quinazolinone 2-TRICHLOROMETHYL-4(3 H)-QUINAZOLINONE 2-trichloromethyl-3H-quinazoline-4-one 2-(trichloromethyl)quinazolin-4(1H)-one 2-(TRICHLOROMETHYL)QUINAZOLIN-4(3H)-ONE 2-(Trichloromethyl)quinazoline-4(3H)-one 4(3H)-Quinazolinone, 2-(trichloromethyl)- 2-(Trichloromethyl)-3,4-dihydroquinazoline-4-one
CAS	5558-95-2
EINECS	226-927-2
InChI	InChI=1/C9H5Cl3N2O/c10-9(11,12)8-13-6-4-2-1-3-5(6)7(15)14-8/h1-4H,(H,13,14,15)

2-Trichloromethyl-4(3H)-quinazolinone - Physico-chemical Properties

Molecular Formula	C9H5Cl3N2O
Molar Mass	263.51
Density	1.64g/cm³
Melting Point	211-213°C(lit.)
Boling Point	330.8°C at 760 mmHg
Flash Point	153.9°C
Vapor Presure	0.000162mmHg at 25°C
Refractive Index	1.673

2-Trichloromethyl-4(3H)-quinazolinone - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3

2-Trichloromethyl-4(3H)-quinazolinone - Introduction

2-Tricholomethyl-4 (3H)-quinazolinone is an organic compound with the chemical formula C9H5Cl3N2O.

Nature:
2-Tricholomethyl-4 (3H)-quinazolinone is a white solid with a special chemical structure. It is relatively stable at room temperature, poor solubility, difficult to dissolve in water, more easily dissolved in some organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane.

Use:
2-Tricholomethyl-4 (3H)-quinazolinone has a wide range of applications in the field of pharmaceutical research. Its derivatives have anti-cancer, anti-virus, anti-bacterial, anti-inflammatory and anti-parasitic biological activities, so they are widely studied as drug candidate compounds. The compound is also commonly used in organic synthesis, as a synthetic intermediate involved in the preparation of organic compounds.

Preparation Method:
At present, there are two main methods for preparing 2-Tricholomethyl-4 (3H)-quinazolinone. One is prepared by acid-base action of amide and chlorination of chloroacetyl chloride; the other is synthesized by benzotrichloroketone and ammonia.

Safety Information:
The safety and toxicity profile of 2-Tricholomethyl-4 (3H)-quinazolinone has not been established. Therefore, the use and handling of the substance should follow the general chemical laboratory safety procedures, take appropriate personal protective measures, and avoid direct contact with skin, eyes and respiratory system.

Last Update：2024-04-09 20:48:19