2-甲磺酰基乙酸
Methanesulfonylacetic Acid
CAS: 2516-97-4
Molecular Formula: C3H6O4S
2-甲磺酰基乙酸 - Names and Identifiers
2-甲磺酰基乙酸 - Physico-chemical Properties
| Molecular Formula | C3H6O4S |
| Molar Mass | 138.14 |
| Density | 1.474 |
| Melting Point | 118-120°C |
| Boling Point | 423.6±28.0 °C(Predicted) |
| Water Solubility | Soluble in water. |
| BRN | 1760342 |
| pKa | pK1:2.36 (25°C) |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD00051843 |
2-甲磺酰基乙酸 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
2-甲磺酰基乙酸 - Reference Information
| Use | methanesulfonylacetic acid is a raw material for the synthesis of pharmaceuticals and agrochemicals, which is used as a synthetic herbicide, the use of intermediates for antibiotics and bleach activators is particularly important. Methanesulfonyl Group is a group often introduced in the synthesis of pharmaceutical and chemical intermediates, and has a variety of biological activities. |
| preparation | 4-methylthioethane is used as raw material, which is firstly chloromethylated to produce 4-methylthiochloroethane, magnesium is then added to form a Grignard reagent, hydrolyzed with carbon dioxide to give 4-methylthioacetic acid, and finally oxidized to 4-methanesulfonylacetic acid. In the synthetic route, the Grignard reagent reaction requires high requirements, and must be anhydrous and oxygen-free, and the experimental operation requirements are also high, thus increasing the difficulty of industrialization. In this paper, 1-chloro-2-(methylthio) ethane is used as raw material, and 4-methylthioacetic acid is obtained by hydrolysis after cyano nucleophilic substitution, and finally oxidized to methylsulfonyl acetic acid. Its synthetic route is shown in Figure 1. In the synthetic route, sodium hydride has serious toxic environmental pollution, more nucleophilic substitution by-products, and higher reaction operation requirements, which is not conducive to industrial production and environmental friendliness. |
Last Update：2024-04-09 20:49:11
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View History
2-甲磺酰基乙酸
ethane,1-chloro-2-methoxy
50850-19-6
3-Anilinopropionitrile
咪鲜胺(咪酰胺)
Chlorotrifluoroethylene
N,N-DIISOPROPYLANILI
171366-19-1
5-Chloro-2-methylbenzoic acid
adecyl triphenyl phosphonium bromide
ethane,1-chloro-2-methoxy
50850-19-6
3-Anilinopropionitrile
咪鲜胺(咪酰胺)
Chlorotrifluoroethylene
N,N-DIISOPROPYLANILI
171366-19-1
5-Chloro-2-methylbenzoic acid
adecyl triphenyl phosphonium bromide