200626-61-5
Benzotriazol-1-yl-(2,4-Dichloro-Phenyl)-Methanone
CAS: 200626-61-5
Molecular Formula: C13H7Cl2N3O
200626-61-5 - Names and Identifiers
200626-61-5 - Physico-chemical Properties
| Molecular Formula | C13H7Cl2N3O |
| Molar Mass | 292.12 |
| Melting Point | 119-121°C |
| Solubility | DMSO: ~28mg/mL |
| Appearance | solid |
| Color | White to Off-White |
| Storage Condition | Inert atmosphere,2-8°C |
| In vitro study | ITSA1 (50 μM; A549 cells) treatment serves to revert the TSA-arrested population to a normal cell cycle distribution. ITSA1 is also able to effect cell cycle rescue over longer duration. ITSA1 (50 μM; 5 hours; A549 cells) treatment reduces the number of apoptosis in TSA-treated cells. ITSA1 (50 μM; 2 hours; A549 and murine ES cells cells) treatment suppresses TSA-induced histone acetylation. Importantly, suppression of acetylation levels is only observable when ITSA1 is added concurrent with or post TSA treatment. ITSA1 (50 μM; 30 minutes; murine ES cells cells) suppresses TSA-activated transcription in murine ES cells. Cell Cycle Analysis Cell Line: Murine ES cells Concentration: 50 μM Incubation Time: Result: Served to revert the TSA-arrested population to a normal cell cycle distribution. Apoptosis Analysis Cell Line: A549 cells Concentration: 50 μM Incubation Time: 5 hours Result: Reduced the number of apoptosis. Western Blot Analysis Cell Line: A549 and murine ES cells Concentration: 50 μM Incubation Time: 2 hours Result: Reduced histone acetylation to the baseline level. RT-PCR Cell Line: Murine ES cells Concentration: 50 μM Incubation Time: 30 minutes Result: Suppressed TSA-activated transcription. |
| In vivo study | ITSA-1 (0.5 mg/kg; intraperitoneal injection; 3 times/week; for 8 weeks; CBS +/− mice) treatment balances deacetylation activity and suppresses IL-6 and TNF-α expression and thereby attenuated histone acetylationdependent infammatory signaling. Animal Model: CBS +/− mice Dosage: 0.5 mg/kg Administration: Intraperitoneal injection; 3 times/week; for 8 weeks Result: Balanced deacetylation activity and suppressed IL-6 and TNF-α expression. |
200626-61-5 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
200626-61-5 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.423 ml | 17.116 ml | 34.233 ml |
| 5 mM | 0.685 ml | 3.423 ml | 6.847 ml |
| 10 mM | 0.342 ml | 1.712 ml | 3.423 ml |
| 5 mM | 0.068 ml | 0.342 ml | 0.685 ml |
Last Update：2024-01-02 23:10:35
200626-61-5 - Reference Information
| biological activity | ITSA-1 is an activator of HDAC, which can offset trichostatin A (trichostatin A, TSA)-induced cell cycle arrest, histone acetylation and transcription levels. |
| target | HDAC |
| in vitro study | ITSA1 (50 μM; a549 cells) treatment serves to revert the TSA-arrested population to a normal cell cycle distribution. ITSA1 is also able to effect cell cycle over longer duration. ITSA1 (50 μ M; 5 hours; A549 cells) treatment reduces the number of apoptosis in TSA-treated cells. ITSA1 (50 μ M; 2 hours; A549 and murine es cells) treatment suppresses TSA-induced histone acetylation. Importantly, suppression of acetylation levels is only observable when ITSA1 is added concurrent with or post TSA treatment. ITSA1 (50 μ M; 30 minutes; Murine ES cells) suppresses TSA-activated transcription in murine ES cells. Cell Cycle Analysis Cell Line: Murine ES cells Concentration: 50 μ m Incubation Time: Result: Served to reverse the TSA-arrested population to a normal cell distribution. Apoptosis Analysis Cell Line: A549 cells Concentration: 50 μM Incubation Time: 5 hours Result: Reduced the number of apoptosis. Western Blot Analysis Cell Line: A549 and murine ES cells Concentration: 50 μM Incubation Time: 2 hours Result: Reduced histone acetylation to the baseline level. RT-PCR Cell Line: Murine ES cells Concentration: 50 μM Incubation Time: 30 minutes Result: suppressed TSA-activated transcription. |
| Cell Line: | Murine ES cells A549 cells A549 and murine ES cells Murine ES cells |
| Concentration: | 50 μM 50 μM 50 μM 50 μM |
| Incubation Time: | 5 hours 2 hours 30 minutes |
| Result: | Served to revert the TSA-arrested population to a normal cell cycle distribution. Reduced the number of apoptosis. Reduced histone acetylation to the baseline level. Suppressed TSA-activated transcription. Balanced deacetylation activity and suppressed IL-6 and TNF-α expression. |
| in vivo study | ITSA-1 (0.5 mg/kg; intraperitoneal injection; 3 times/week; for 8 weeks; CBS /− nice) treatment balances deacetylation activity and suppresses IL-6 and TNF-α expression and thereby attenuated histone acetylationdependent infammatory signaling. Animal Model: CBS /− nice Dosage: 0.5 mg/kg Administration: Intraperitoneal injection; 3 times/week; for 8 weeks Result: Balanced deacetylation activity and suppressed IL-6 and TNF-α expression. |
| Animal Model: | CBS /− mice |
| Dosage: | 0.5 mg/kg |
| Administration: | Intraperitoneal injection; 3 times/week; for 8 weeks |
Last Update：2024-04-10 22:29:15
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: ITSA-1 Request for quotationCAS: 200626-61-5
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Multiple SpecificationsSpot supply
Product Name: ITSA-1 (Standard) Visit Supplier Webpage Request for quotationCAS: 200626-61-5
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Benzotriazol-1-yl-(2,4-Dichloro-Phenyl)-Methanone Visit Supplier Webpage Request for quotationCAS: 200626-61-5
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Product Name: Benzotriazol-1-yl-(2,4-Dichloro-Phenyl)-Methanone Visit Supplier Webpage Request for quotation
CAS: 200626-61-5
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CAS: 200626-61-5
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Email: 3008007409@qq.com
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