201478-72-0
N-Cbz-3-piperidinylcarboxaldehyde
CAS: 201478-72-0
Molecular Formula: C14H17NO3
201478-72-0 - Names and Identifiers
| Name | N-Cbz-3-piperidinylcarboxaldehyde |
| Synonyms | Zinc02577450 N-CBZ-3-FORMYLPIPERIDINE 1-Cbz-3-forMyl-piperidine N-CBZ-3-piperidinecarboxaldehyde N-Cbz-3-piperidinylcarboxaldehyde N-CBZ-3-PIPERIDINYLCARBOXALDEHYDE benzyl 3-formylpiperidine-1-carboxylate Piperidine-3-carboxaldehyde, N-CBZ protected Benzyl 3-formylpiperidine-1-carboxylate, 1-[(Benzyloxy)carbonyl]-3-formylpiperidine |
| CAS | 201478-72-0 |
| InChI | InChI=1/C14H17NO3/c16-10-13-7-4-8-15(9-13)14(17)18-11-12-5-2-1-3-6-12/h1-3,5-6,10,13H,4,7-9,11H2 |
201478-72-0 - Physico-chemical Properties
| Molecular Formula | C14H17NO3 |
| Molar Mass | 247.29 |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| Boling Point | 384.5±42.0 °C(Predicted) |
| Flash Point | 186.341°C |
| Vapor Presure | 0mmHg at 25°C |
| pKa | -2.34±0.40(Predicted) |
| Storage Condition | -20℃ |
| Refractive Index | 1.594 |
201478-72-0 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Note | Irritant |
201478-72-0 - Introduction
N-Cbz-3-piperidinylcarboxaldehyde is an organic compound whose chemical name is N-(benzyloxycarbonyl)-3-piperidinemethanol. The following is an introduction to some of its properties, uses, methods and safety information:
Nature:
N-Cbz-3-piperidinylcarboxaldehyde is a solid with a specific molecular structure. Its chemical formula is C15H19NO3 and its relative molecular mass is 261.32. It is usually colorless or light yellow crystalline and can be dissolved in organic solvents. It is a stable compound, but may decompose at high temperatures.
Use:
N-Cbz-3-piperidinylcarboxaldehyde is widely used in organic synthesis. It is an important intermediate, which can be used to prepare a variety of organic compounds, such as drugs, pesticides, dyes and so on. It can be used as an Amine protecting group to protect the amine group and prevent it from unwanted reactions, and can be easily removed after the reaction is completed.
Method:
The preparation method of N-Cbz-3-piperidinylcarboxaldehyde is more diverse, the common method is obtained by the reaction of piperidine and benzyl chloroformate under alkaline conditions. The specific step is to first react piperidine with benzyl chloroformate to generate N-(benzyloxycarbonyl)-3-piperidinemethyl chloride, and then hydrolyze it under alkaline conditions to obtain N-Cbz-3-piperidinylcarboxaldehyde.
Safety Information:
N-Cbz-3-piperidinylcarboxaldehyde need to pay attention to safety during use. It may cause irritation to the skin, eyes and respiratory tract, so wear appropriate personal protective equipment such as safety glasses, gloves and masks when using it. If inhaled, ingested, or exposed to the compound, rinse immediately with plenty of water and seek medical attention. During storage, it should be kept away from fire sources, oxidants, strong acids, strong alkalis and other substances, and the ventilation conditions of the storage area should be improved.
Nature:
N-Cbz-3-piperidinylcarboxaldehyde is a solid with a specific molecular structure. Its chemical formula is C15H19NO3 and its relative molecular mass is 261.32. It is usually colorless or light yellow crystalline and can be dissolved in organic solvents. It is a stable compound, but may decompose at high temperatures.
Use:
N-Cbz-3-piperidinylcarboxaldehyde is widely used in organic synthesis. It is an important intermediate, which can be used to prepare a variety of organic compounds, such as drugs, pesticides, dyes and so on. It can be used as an Amine protecting group to protect the amine group and prevent it from unwanted reactions, and can be easily removed after the reaction is completed.
Method:
The preparation method of N-Cbz-3-piperidinylcarboxaldehyde is more diverse, the common method is obtained by the reaction of piperidine and benzyl chloroformate under alkaline conditions. The specific step is to first react piperidine with benzyl chloroformate to generate N-(benzyloxycarbonyl)-3-piperidinemethyl chloride, and then hydrolyze it under alkaline conditions to obtain N-Cbz-3-piperidinylcarboxaldehyde.
Safety Information:
N-Cbz-3-piperidinylcarboxaldehyde need to pay attention to safety during use. It may cause irritation to the skin, eyes and respiratory tract, so wear appropriate personal protective equipment such as safety glasses, gloves and masks when using it. If inhaled, ingested, or exposed to the compound, rinse immediately with plenty of water and seek medical attention. During storage, it should be kept away from fire sources, oxidants, strong acids, strong alkalis and other substances, and the ventilation conditions of the storage area should be improved.
Last Update：2024-04-09 20:49:11
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CAS: 201478-72-0
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