204205-90-3
Indibulin
CAS: 204205-90-3
Molecular Formula: C22H16ClN3O2
204205-90-3 - Names and Identifiers
| Name | Indibulin |
| Synonyms | ZIO 301 Nascapine lindiblin Indibulin 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide 2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)acetamide 1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl- 2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide |
| CAS | 204205-90-3 |
| InChI | InChI=1/C22H16ClN3O2/c23-16-7-5-15(6-8-16)13-26-14-19(18-3-1-2-4-20(18)26)21(27)22(28)25-17-9-11-24-12-10-17/h1-12,14H,13H2,(H,24,25,28) |
204205-90-3 - Physico-chemical Properties
| Molecular Formula | C22H16ClN3O2 |
| Molar Mass | 389.83 |
| Density | 1.31±0.1 g/cm3(Predicted) |
| pKa | 9.38±0.70(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.664 |
| In vitro study | Indibulin (300-2100 nM; 48 hours) inhibits the proliferation of MCF-7 cells with an IC50 of 150 nM. Indibulin (300, 600 nM; 48 hours) blockes the cells in the G2/M phase indicating that indibulin blockes the progression of the cell cycle at mitosis. Indibulin (150-600 nM; 24 hours) induces apoptosis in MCF-7 cells. Indibulin (150-600 nM; 48 hours) with 300 and 600 nM generates cleaved fragments of PARP protein the treatment of MCF-7 cells. Cell Proliferation Assay Cell Line: MCF-7 cells Concentration: 300, 600, 900, 1200, 1500, 1800, 2100 nM Incubation Time: 48 hours Result: Inhibited the proliferation of MCF-7 cells with an IC 50 of 150 nM. Cell Cycle Analysis Cell Line: MCF-7 cells Concentration: 300, 600 nM Incubation Time: 48 hours Result: Blocked the cells in the G2/M phase of the cell cycle. Apoptosis Analysis Cell Line: MCF-7 cells Concentration: 150, 300 and 600 nM Incubation Time: 24 hours Result: Induced apoptosis in MCF-7 cells. Western Blot Analysis Cell Line: MCF-7 cells Concentration: 150, 300 and 600 nM Incubation Time: 48 hours Result: Generated cleaved fragments of PARP protein in 300 and 600 nM. |
204205-90-3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.565 ml | 12.826 ml | 25.652 ml |
| 5 mM | 0.513 ml | 2.565 ml | 5.13 ml |
| 10 mM | 0.257 ml | 1.283 ml | 2.565 ml |
| 5 mM | 0.051 ml | 0.257 ml | 0.513 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide Visit Supplier Webpage Request for quotation
CAS: 204205-90-3
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CAS: 204205-90-3
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