205304-86-5
Tubulysin A
CAS: 205304-86-5
Molecular Formula: C43H65N5O10S
205304-86-5 - Names and Identifiers
205304-86-5 - Physico-chemical Properties
| Molecular Formula | C43H65N5O10S |
| Molar Mass | 844.07 |
| Density | 1.195±0.06 g/cm3(Predicted) |
| Melting Point | 106-108 °C(Solv: methanol (67-56-1); water (7732-18-5)) |
| Boling Point | 979.9±65.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| Appearance | film |
| Color | colorless or white |
| pKa | 4.52±0.23(Predicted) |
| Storage Condition | 2-8°C |
205304-86-5 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
205304-86-5 - Introduction
Tubulysin A is a natural product with antitumor activity. It is a small molecule antibiotic produced by Gram-positive bacteria belonging to Myxobacteria. The chemical structure of Tubulysin A is complex, containing multiple thioether and amide structures. It is able to interfere with the process of cell division by binding to and inhibiting tubulin (tubulin) polymerization, which leads to tumor cell death.
Tubulysin A has potential application value in the field of cancer treatment. Studies have shown that it has strong anti-tumor activity against a variety of cancer cell lines, including breast cancer, colorectal cancer, lung cancer and so on. Tubulysin A, as an anti-cancer drug targeting tumor cells, is expected to be used to develop new chemotherapy drugs or combined with other drugs to enhance the therapeutic effect.
The production method of Tubulysin A is generally obtained by extraction and purification from the production strain. The preparation process requires a series of separation, concentration, chromatography and purification steps, including column chromatography, high performance liquid chromatography and other means.
Regarding the safety information of Tubulysin A, it is a strongly cytotoxic compound that is potentially harmful to the human body and the environment. Due to the risk of side effects and toxicity, the use of Tubulysin A requires strict safety practices and controls. In laboratory and industrial production, it is necessary to follow relevant safety procedures, such as wearing protective clothing and using chemical ventilation equipment. In addition, because Tubulysin A acts on tubulin, it may cause cell dysfunction, and more research and evaluation in clinical application are needed to ensure its safety.
Please note that the above information is for reference only. Always seek professional advice and guidance before using Tubulysin A or any other compounds.
Tubulysin A has potential application value in the field of cancer treatment. Studies have shown that it has strong anti-tumor activity against a variety of cancer cell lines, including breast cancer, colorectal cancer, lung cancer and so on. Tubulysin A, as an anti-cancer drug targeting tumor cells, is expected to be used to develop new chemotherapy drugs or combined with other drugs to enhance the therapeutic effect.
The production method of Tubulysin A is generally obtained by extraction and purification from the production strain. The preparation process requires a series of separation, concentration, chromatography and purification steps, including column chromatography, high performance liquid chromatography and other means.
Regarding the safety information of Tubulysin A, it is a strongly cytotoxic compound that is potentially harmful to the human body and the environment. Due to the risk of side effects and toxicity, the use of Tubulysin A requires strict safety practices and controls. In laboratory and industrial production, it is necessary to follow relevant safety procedures, such as wearing protective clothing and using chemical ventilation equipment. In addition, because Tubulysin A acts on tubulin, it may cause cell dysfunction, and more research and evaluation in clinical application are needed to ensure its safety.
Please note that the above information is for reference only. Always seek professional advice and guidance before using Tubulysin A or any other compounds.
Last Update：2024-04-09 21:54:55
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View History
205304-86-5
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