| Molecular Formula | C19H41NO9 |
| Molar Mass | 427.53 |
| Density | 1.060 |
| Boling Point | 484.3±40.0 °C(Predicted) |
| pKa | 8.74±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| In vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| biological activity | m-PEG9-Amine is a PROTAC connection bridge and belongs to PEG class. m-PEG9-Amine can be used to synthesize a series of PROTAC molecules. m-PEG9-Amine is a degradable (cleavable) ADC connection bridge for the synthesis of antibody drug conjugates (ADCs). |
| target | Cleavable PEGs |
| in vitro study | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |