218278-58-1

218278-58-1 - Names and Identifiers

Name	1-Boc-4-Fmoc-2-piperazinecarboxylic acid
Synonyms	1-Boc-4-Fmoc-2-piperazinecarboxylic acid 1-BOC-4-FMOC-PIPERAZINE-2-CARBOXYLIC ACID N1-BOC-N4-FMOC-PIPERAZINE-2-CARBOXYLIC ACID 1-N-BOC-4-N-FMOC-PIPERAZINE-2-CARBOXYLIC ACID N-1-BOC-N-4-FMOC-2-PIPERAZINE CARBOXYLIC ACID PIPERAZINE-2-CARBOXYLIC ACID, N1-BOC PROTECTED, N4-FMOC PROTECTED PIPERAZINE-1,2,4-TRICARBOXYLIC ACID 1-TERT-BUTYL ESTER 4-(9H-FLUOREN-9-YLMETHYL) ESTER 1-(tert-butoxycarbonyl)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylic acid 1-(TERT-BUTOXYCARBONYL)-4-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-2-PIPERAZINECARBOXYLIC ACID 1-(tert-Butoxycarbonyl)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-piperazinecarboxylic acid (2S)-1-(tert-butoxycarbonyl)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylate (2R)-1-(tert-butoxycarbonyl)-4-[(9H-fluoren-9-ylmethoxy)carbonyl]piperazine-2-carboxylate
CAS	218278-58-1
InChI	InChI=1/C25H28N2O6/c1-25(2,3)33-24(31)27-13-12-26(14-21(27)22(28)29)23(30)32-15-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,20-21H,12-15H2,1-3H3,(H,28,29)/p-1/t21-/m1/s1

218278-58-1 - Physico-chemical Properties

Molecular Formula	C25H28N2O6
Molar Mass	452.5
Density	1.292±0.06 g/cm3(Predicted)
Melting Point	156 °C
Boling Point	624.4±55.0 °C(Predicted)
Flash Point	331.4°C
Vapor Presure	1.88E-16mmHg at 25°C
pKa	3.68±0.20(Predicted)
Storage Condition	2-8°C

218278-58-1 - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust.

218278-58-1 - Introduction

acid (acid) is an organic compound. Its chemical formula is c₂ H, and its molecular weight is 421.48g/mol. It is a white crystalline or powdery solid and is soluble in some organic solvents such as dimethylsulfite (DMSO) and dimethylformamide (DMF).

This compound is commonly used in the reaction of protecting groups in organic synthesis. It can be used as an N-protecting group to protect some amino or imine compounds to prevent them from undergoing non-selective functional group conversion in the reaction. In addition, it can also be used to prepare different drugs and bioactive molecular intermediates.

Preparation of acid Generally, starting from 4-Fluoroaniline, N-(4-Fluorophenyl)piperazine(N-4-fluorophenyl piperazine) is first prepared. The target product is then obtained by Boc protection of piperazine followed by Fmoc protection at the 1-position. During the synthesis, attention should be paid to the operating temperature and reaction conditions to ensure high yield and purity.

Regarding safety information, acid is a chemical and should be handled in accordance with relevant laboratory safety procedures. It may be irritating and damaging to the eyes, skin and respiratory system, so appropriate protective measures, such as wearing protective glasses, gloves and respiratory protective equipment, should be taken. During use, avoid inhaling its dust or solution and avoid skin contact. In case of accidental contact, rinse immediately with plenty of water and seek medical help if necessary.

Last Update：2024-04-09 20:49:11