220991-20-8
2-[2-(2-Chloro-6-fluorophenylamino)-5-methylphenyl]acetic acid
CAS: 220991-20-8
Molecular Formula: C15H13ClFNO2
220991-20-8 - Names and Identifiers
| Name | 2-[2-(2-Chloro-6-fluorophenylamino)-5-methylphenyl]acetic acid |
| Synonyms | COX 189 Prexige CGS 35189 Lumaricoxib Lumiracoxib Unii-V91T9204hu 2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic Acid {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid 2-[2-(2-Chloro-6-fluorophenylamino)-5-methylphenyl]acetic acid Benzeneacetic acid, 2-((2-chloro-6-fluorophenyl)amino)-5-methyl- 2-[2-[(2-chloro-6-fluoro-phenyl)amino]-5-methyl-phenyl]acetic acid |
| CAS | 220991-20-8 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12(15)17/h2-7,18H,8H2,1H3,(H,19,20) |
220991-20-8 - Physico-chemical Properties
| Molecular Formula | C15H13ClFNO2 |
| Molar Mass | 293.72 |
| Density | 1.363±0.06 g/cm3(Predicted) |
| Melting Point | 139-141°C |
| Boling Point | 395.7±42.0 °C(Predicted) |
| Flash Point | 193.1°C |
| Vapor Presure | 5.68E-07mmHg at 25°C |
| pKa | 4.18±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Refractive Index | 1.628 |
| Use | Anti-arthritis drugs |
| In vitro study | Lumiracoxib acts on dermal fibroblasts expressing COX-2 with an IC50 of 0.14 μm, but acts on HEK 293 cells transfected with human COX-1 at concentrations up to 30 μm, nor does it inhibit COX-1. In the human whole blood assay, Lumiracoxib acts on COX-2 with an IC50 of 0.13 μm, acts on COX-1, the IC50 was 67 μm (COX-1/COX-2 selectivity ratio of 515). |
| In vivo study | Lumiracoxib is a highly selective COX-2 inhibitor with anti-inflammatory, analgesic and antipyretic activity compared to Diclofenac, a reference NSAID, but with greatly improved gastrointestinal safety. Lumiracoxib was absorbed rapidly in rats treated orally, reaching peak plasma concentrations between 0.5 and 1 hour. Lumiracoxib treated rat models of hyperalgesia, edema, fever and arthritis with similar effects to Diclofenac in a dose-dependent manner. However, consistent with Lumiracoxib having low COX-1 inhibitory activity, Lumiracoxib did not cause ulceration when treated orally at a dose of 100 mg/kg and was significantly less ulcerogenic than Diclofenac. |
220991-20-8 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.405 ml | 17.023 ml | 34.046 ml |
| 5 mM | 0.681 ml | 3.405 ml | 6.809 ml |
| 10 mM | 0.34 ml | 1.702 ml | 3.405 ml |
| 5 mM | 0.068 ml | 0.34 ml | 0.681 ml |
Last Update：2024-01-02 23:10:35
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