221142-28-5

221142-28-5 - Names and Identifiers

Name	(3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid
Synonyms	Boc-trans-DL-b-Pro-4-(phenyl)-OH Boc-(3R,4S)-trans-4-Phenyl-beta-proline trans-1-Boc-4-phenyl-3-pyrrolidinecarboxylic acid 4-PHENYL-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid 1-[(Tert-Butyl)Oxycarbonyl]-4-Phenylpyrroline-3-Carboxylic Acid 1-[(TERT-BUTYL)OXYCARBONYL]-4-PHENYLPYRROLINE-3-CARBOXYLIC ACID trans-N-(tert-Butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid (3S,4R)-1-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid rel-(3R,4S)-1-(tert-Butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid
CAS	221142-28-5 884048-45-7
InChI	InChI=1/C16H21NO4/c1-16(2,3)21-15(20)17-9-12(13(10-17)14(18)19)11-7-5-4-6-8-11/h4-8,12-13H,9-10H2,1-3H3,(H,18,19)

221142-28-5 - Physico-chemical Properties

Molecular Formula	C16H21NO4
Molar Mass	291.34
Density	1.196g/cm³
Boling Point	441.5°C at 760 mmHg
Flash Point	220.8°C
Vapor Presure	1.43E-08mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.548

221142-28-5 - Risk and Safety

HS Code

29339900

221142-28-5 - Introduction

(3S,4R)-1-(tert-butoxycarbonyl)-acid ((3S,4R)-1-(tert-butoxycarbonyl)-acid) is an organic compound, its chemical formula is C17H21NO4.

Nature:
-Appearance: White crystalline solid
-Melting point: approximately in the range of 140-144 ° C
-Solubility: Soluble in common organic solvents, such as alcohols, ethers and chlorinated hydrocarbons
-Stability: relatively stable at room temperature

Use:
(3S,4R)-1-(tert-butoxycarbonyl)-acid is an important organic synthesis intermediate, often used in the synthesis of drugs, pesticides and other organic compounds. One common use of it is as a protecting group in peptide synthesis for the synthesis of specific structures and functions of compounds.

Method:
Preparation of (3S,4R)-1-(tert-butoxycarbonyl)-sulfuric acid is generally carried out by the following steps:
1. The reaction raw material 1: 4-phenylpyrrolidine-3-carbaldehyde reacts with the reaction raw material 2:N,N-dibenzamide to generate 4-phenylpyrrolidine-3-carboxylic acid dibenzyl ester.
2. Reaction raw material 3: p-toluenesulfonic acid and N-phenyl-N'-tert-butyl nitrile react to produce p-toluenesulfonic acid-N-phenyl-N'-tert-butyl nitrile.
3. Reaction raw material 4: P-toluenesulfonic acid-N-phenyl-N'-tert-butyl nitrile and 4-phenylpyrrolidine-3-carboxylic acid diphenyl methyl ester are synthesized, diphenylmethyl trans-N-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylate is produced.
4. Reaction raw material 5: Trans-N-(tert-butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid diphenyl methyl ester reacts with hydrochloric acid to generate (3S,4R)-1-(tert-butoxycarbonyl)-acid.

Safety Information:
(3S,4R)-1-(tert-butoxycarbonyl)-The acid is relatively safe for the human body under normal conditions of use. However, as a chemical, appropriate laboratory practices and personal protective measures should be followed. Avoid contact with eyes and skin, and avoid inhaling gas or swallowing during operation. If splashed on the eyes or skin, rinse immediately with water and seek medical help. Follow proper waste handling procedures when handling and storing.

Last Update：2024-04-09 20:45:29