221243-82-9
4-Amino-1-tert-butyl-3-(1'-naphthyl)pyrazolo[3,4-d]pyrimidine
CAS: 221243-82-9
Molecular Formula: C19H19N5
221243-82-9 - Names and Identifiers
221243-82-9 - Physico-chemical Properties
| Molecular Formula | C19H19N5 |
| Molar Mass | 317.39 |
| Melting Point | 219-222°C |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
221243-82-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.151 ml | 15.753 ml | 31.507 ml |
| 5 mM | 0.63 ml | 3.151 ml | 6.301 ml |
| 10 mM | 0.315 ml | 1.575 ml | 3.151 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
221243-82-9 - Reference Information
| introduction | important progress has been made in the research and development of bioactive molecules based on pyrazolo [3,4-d] pyrimidine structure, such as anti-tumor activity, antibacterial activity, antiviral activity and anti-inflammatory activity. Therefore, it is of great significance and value to study the synthesis of the parent nuclei of pyrazolo [3,4-d] pyrimidine compounds and provide a preliminary basis for the research and development of highly effective anti-tumor drugs. |
| biological activity | 1-Naphthyl PP1 (1-NA-PP 1) is a highly selective and effective pan-PKD inhibitor with IC50 values of 154.6 nM, 133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3 respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl. IC50 values for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II are 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM respectively. |
| target | TargetValue PKD3 (Cell-free Assay) 109.4 nM PKD2 (Cell-free Assay) 133.4 nM PKD1 (Cell-free Assay) 154.6 nM v-Fyn (Cell-free Assay) 0.6 μM c-Abl (Cell-free Assay) 0.6 μM |
| Target | Value |
| PKD3 (Cell-free assay) | 109.4 nM |
| PKD2 (Cell-free assay) | 133.4 nM |
| PKD1 (Cell-free assay) | 154.6 nM |
| v-Fyn (Cell-free assay) | 0.6 μM |
| c-Abl (Cell-free assay) | 0.6 μM |
Last Update：2024-04-09 21:01:54
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