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22235-81-0

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate

CAS: 22235-81-0

Molecular Formula: C19H27NO3

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22235-81-0 - Names and Identifiers

Name endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
Synonyms Ipratropium Impurity E
N-Isopropylnoratropine
N-DesMethyl IpratropiuM
Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E)
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester
α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester
α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester
α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester
rac-(R*)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-isopropyl-8-azabicyclo[3.2.1]octane-3α-yl ester
CAS 22235-81-0
EINECS 2448591

22235-81-0 - Physico-chemical Properties

Molecular FormulaC19H27NO3
Molar Mass317.42258
Density1.15±0.1 g/cm3(Predicted)
Melting Point112-114°C
Boling Point448.8±45.0 °C(Predicted)
Solubility Chloroform (Slightly), Methanol (Slightly)
AppearanceSolid
ColorWhite to Pale Orange
pKa14.12±0.10(Predicted)
Storage ConditionRefrigerator

22235-81-0 - Upstream Downstream Industry

Raw MaterialsNoratropine
endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
Acetyltropylic chloride
Ethyl phenylacetate
Atropine
Acetone

22235-81-0 - Introduction

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl is an organic compound with the chemical name endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl.

Nature:
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl is a white crystalline solid, insoluble in water at room temperature, soluble in some organic solvents such as ethanol and Ether solvents. Its structure contains eight-membered heterocyclic ring, in which the nitrogen atom and the hydroxy methyl group on the benzene ring make it have special chemical properties.

Use:
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl is mainly used in the field of drug research and manufacturing. It is an impurity of the peripheral anticholinergic drug ipratropium bromide. It is used to detect the purity and quality of ipratropium bromide products and perform quality control.

Method:
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1] The preparation method of oct-3-yl (hydroxymethyl)phenylacetate is generally realized by organic synthetic chemical reaction. Specific methods include the synthesis of intermediate compounds followed by specific reaction steps to give the final product.

Safety Information:
Last Update:2024-04-09 02:00:51
22235-81-0
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Hubei Rhema Reference Materials Technology Co., Ltd.
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Hubei Rhema Reference Materials Technology Co., Ltd.
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Product Name: Ipratropium Bromide EP Impurity E Request for quotation
CAS: 22235-81-0
Tel: 0712-8899838
Email: jy6101@rmastandards.com
Mobile: 86-15787876101
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Wechat: 15787876101
Shanghai Amole Biotechnology Co., Ltd.
Spot supply
Product Name: N-Isopropylnoratropine Request for quotation
CAS: 22235-81-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
Shanghai Macklin Biochemical Co., Ltd
Spot supply
Product Name: N-Isopropylnoratropine (NINA) Visit Supplier Webpage Request for quotation
CAS: 22235-81-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328 Click to send a QQ message
WhatsApp: +86-18821248368
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: N-Isopropylnoratropine Visit Supplier Webpage Request for quotation
CAS: 22235-81-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
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View History
22235-81-0
Raw Materials for 22235-81-0
Noratropine
endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
Acetyltropylic chloride
Ethyl phenylacetate
Atropine
Acetone
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