22353-41-9
2-bromo-3-chloro-5-nitropyridine
CAS: 22353-41-9
Molecular Formula: C5H2BrClN2O2
22353-41-9 - Names and Identifiers
| Name | 2-bromo-3-chloro-5-nitropyridine |
| Synonyms | 2-BROMO-3-CHLORO-5-NITROPYRIDINE 2-bromo-3-chloro-5-nitropyridine Pyridine, 2-bromo-3-chloro-5-nitro- pyridine, 2-bromo-3-chloro-5-nitro- |
| CAS | 22353-41-9 |
| EINECS | 125-856-9 |
| InChI | InChI=1/C5H2BrClN2O2/c6-5-4(7)1-3(2-8-5)9(10)11/h1-2H |
22353-41-9 - Physico-chemical Properties
| Molecular Formula | C5H2BrClN2O2 |
| Molar Mass | 237.44 |
| Density | 1.936±0.06 g/cm3(Predicted) |
| Melting Point | 62 °C |
| Boling Point | 270 °C |
| Flash Point | 130.7°C |
| Vapor Presure | 0.00319mmHg at 25°C |
| Appearance | Yellow crystal |
| pKa | -5.53±0.20(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.627 |
| MDL | MFCD08061302 |
22353-41-9 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
22353-41-9 - Introduction
Is an organic compound with the chemical formula C5H2BrClN2O2.
It is a yellow crystalline solid with a special aroma. It has a melting point of about 70-72 ° C. And a boiling point of about 315 ° C. The compound is insoluble in water at normal temperature, but soluble in organic solvents such as ethanol, methanol, dimethylformamide and the like.
It is widely used as an important intermediate in organic synthesis. It can be used in the synthesis of various drugs, dyes and pesticides and other organic compounds. For example, it can be used in the synthesis of antibacterial drugs, anti-tumor drugs and pesticides.
The method of preparing phosphonium can be achieved by bromination, nitration and chlorination of pyridine. First, a substitution reaction of pyridine with bromine in acetic acid produces 2-bromopyridine. The 2-bromopyridine is then reacted with chlorine in nitric acid to give 2-bromo-3-chloropyridine. Finally, the target product is obtained by reacting 2-bromo-3-chloropyridine with concentrated nitric acid.
Regarding safety information, this compound is an organic halide, which has certain toxicity and irritation. Contact with the skin or inhalation of its vapors may cause irritation and discomfort. During handling and use, appropriate safety measures should be taken, such as wearing chemical protective gloves, protective glasses and masks, to ensure a well-ventilated working environment. In case of accidental contact or inhalation, move quickly to fresh air and seek medical help immediately.
It is a yellow crystalline solid with a special aroma. It has a melting point of about 70-72 ° C. And a boiling point of about 315 ° C. The compound is insoluble in water at normal temperature, but soluble in organic solvents such as ethanol, methanol, dimethylformamide and the like.
It is widely used as an important intermediate in organic synthesis. It can be used in the synthesis of various drugs, dyes and pesticides and other organic compounds. For example, it can be used in the synthesis of antibacterial drugs, anti-tumor drugs and pesticides.
The method of preparing phosphonium can be achieved by bromination, nitration and chlorination of pyridine. First, a substitution reaction of pyridine with bromine in acetic acid produces 2-bromopyridine. The 2-bromopyridine is then reacted with chlorine in nitric acid to give 2-bromo-3-chloropyridine. Finally, the target product is obtained by reacting 2-bromo-3-chloropyridine with concentrated nitric acid.
Regarding safety information, this compound is an organic halide, which has certain toxicity and irritation. Contact with the skin or inhalation of its vapors may cause irritation and discomfort. During handling and use, appropriate safety measures should be taken, such as wearing chemical protective gloves, protective glasses and masks, to ensure a well-ventilated working environment. In case of accidental contact or inhalation, move quickly to fresh air and seek medical help immediately.
Last Update：2024-04-09 20:02:46
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