22423-26-3
2,2-Anhydro-5-methyluridine
CAS: 22423-26-3
Molecular Formula: C10H12N2O5
22423-26-3 - Names and Identifiers
| Name | 2,2-Anhydro-5-methyluridine |
| Synonyms | 2,2-Anhydro-5-methyluridine 2,2-Anhydro-1-beta-arabinofuranosylthymine 2,2-Anhydro-11-beta-D-arabinofuranosylthymine |
| CAS | 22423-26-3 |
| EINECS | 2017-001-1 |
| InChI | InChI=1/C10H12N2O5/c1-4-2-12-9-7(6(14)5(3-13)16-9)17-10(12)11-8(4)15/h2,5-7,9,13-14H,3H2,1H3/t5-,6-,7+,9-/m1/s1 |
22423-26-3 - Physico-chemical Properties
| Molecular Formula | C10H12N2O5 |
| Molar Mass | 240.22 |
| Density | 1.88g/cm3 |
| Melting Point | 217.0 to 221.0 °C |
| Boling Point | 452°C at 760 mmHg |
| Flash Point | 227.2°C |
| Vapor Presure | 4.54E-10mmHg at 25°C |
| Appearance | White or nearly white crystalline powder |
| pKa | 12.56±0.60(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.772 |
| MDL | MFCD00233555 |
22423-26-3 - Upstream Downstream Industry
| Downstream Products | THYMINE-BETA-D-ARABINOFURANOSIDE |
22423-26-3 - Introduction
2,2-anhydro-5-methyluridine is an organic compound with the chemical formula C10H12N2O6. It is a derivative of uridine, which forms a 2,2 dehydrated structure by removing one water molecule. Its main properties and uses are as follows:
Nature:
2,2-hydroxy-5-methyluridine is a colorless crystalline solid that is stable at room temperature. It is less soluble in water and soluble in some organic solvents such as methanol and dichloromethane. Its melting point is about 145-150°C.
Use:
2,2-hydroxy-5-methyluridine has certain applications in the field of biochemistry and medicine. It can be used as an intermediate for the synthesis of nucleoside drugs, and can also be used for the modification and labeling of nucleotides. In addition, it can also be used to synthesize nucleic acid probes and fluorescent probes, as well as to study the biological functions of nucleotides and enzyme-catalyzed reactions.
Method:
The preparation of 2,2-anhydro-5-methyluridine usually adopts chemical synthesis method. One commonly used method is to generate 2,2-anhydro-5-methyluridine by heating the uridine with an acidic solution (such as anhydrous glacial acetic acid) and dilute sulfuric acid to remove one molecule of water. The temperature and time of the reaction have an effect on the yield and typically require several hours at moderate temperatures.
Safety Information:
There is no large number of literature reports on the safety information of 2,2-anhydro-5-methyluridine. However, for the handling and use of any chemical substance, appropriate safety measures should be taken. This includes wearing appropriate personal protective equipment (such as gloves, protective glasses and laboratory coats), operating in a well-ventilated environment, and following relevant safe operating procedures and guidelines. During use, the stability and purity of the compound should be checked regularly, and waste should be stored and disposed of properly. If necessary, it is recommended to operate under the guidance of experienced chemical professionals.
Nature:
2,2-hydroxy-5-methyluridine is a colorless crystalline solid that is stable at room temperature. It is less soluble in water and soluble in some organic solvents such as methanol and dichloromethane. Its melting point is about 145-150°C.
Use:
2,2-hydroxy-5-methyluridine has certain applications in the field of biochemistry and medicine. It can be used as an intermediate for the synthesis of nucleoside drugs, and can also be used for the modification and labeling of nucleotides. In addition, it can also be used to synthesize nucleic acid probes and fluorescent probes, as well as to study the biological functions of nucleotides and enzyme-catalyzed reactions.
Method:
The preparation of 2,2-anhydro-5-methyluridine usually adopts chemical synthesis method. One commonly used method is to generate 2,2-anhydro-5-methyluridine by heating the uridine with an acidic solution (such as anhydrous glacial acetic acid) and dilute sulfuric acid to remove one molecule of water. The temperature and time of the reaction have an effect on the yield and typically require several hours at moderate temperatures.
Safety Information:
There is no large number of literature reports on the safety information of 2,2-anhydro-5-methyluridine. However, for the handling and use of any chemical substance, appropriate safety measures should be taken. This includes wearing appropriate personal protective equipment (such as gloves, protective glasses and laboratory coats), operating in a well-ventilated environment, and following relevant safe operating procedures and guidelines. During use, the stability and purity of the compound should be checked regularly, and waste should be stored and disposed of properly. If necessary, it is recommended to operate under the guidance of experienced chemical professionals.
Last Update：2024-04-09 20:52:54
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