2252403-56-6
AMG-510 racemate
CAS: 2252403-56-6
Molecular Formula: C30H30F2N6O3
2252403-56-6 - Names and Identifiers
2252403-56-6 - Physico-chemical Properties
| Molecular Formula | C30H30F2N6O3 |
| Molar Mass | 560.59 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Boling Point | 730.5±70.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 6.52±0.35(Predicted) |
| Storage Condition | -20°C |
| Use | AMG-510 racemate are AMG-510 racemes. AMG-510 is an effective, orally bioavailable, selective covalent inhibitor of KRAS G12C with antitumor activity. |
2252403-56-6 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.784 ml | 8.919 ml | 17.838 ml |
| 5 mM | 0.357 ml | 1.784 ml | 3.568 ml |
| 10 mM | 0.178 ml | 0.892 ml | 1.784 ml |
| 5 mM | 0.036 ml | 0.178 ml | 0.357 ml |
Last Update：2024-01-02 23:10:35
2252403-56-6 - Reference Information
| use | AMG-510 is a KRAS G12C inhibitor, which causes KRAS G12C tumor regression because it interrupts protein signaling. An effective, oral bioavailable, selective covalent inhibitor of KRAS G12C. AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells. |
| biological activity | Sotorasib (AMG510) is racemate a racemate of AMG-510. AMG-510 is a potent covalent inhibitor of KRAS G12C with potential antitumor activity. |
| target | TargetValue KRAS G12Cv () |
| Target | Value |
Last Update：2024-04-09 21:54:55
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Product Name: 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one Request for quotationCAS: 2252403-56-6
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Product Name: AMG-510 racemat Visit Supplier Webpage Request for quotationCAS: 2252403-56-6
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Product Name: AMG-510racemate Visit Supplier Webpage Request for quotationCAS: 2252403-56-6
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Product Name: AMG-510 racemate Visit Supplier Webpage Request for quotationCAS: 2252403-56-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
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Product Name: AMG510 Visit Supplier Webpage Request for quotationCAS: 2252403-56-6
Tel: +16314854226
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Product Name: AMG-510 racemate Visit Supplier Webpage Request for quotationCAS: 2252403-56-6
Tel: 18301782025
Email: 3008007409@qq.com
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