2257-69-4
4-chloro-1,2-dihydrophthalazin-1-one
CAS: 2257-69-4
Molecular Formula: C8H5ClN2O
2257-69-4 - Names and Identifiers
| Name | 4-chloro-1,2-dihydrophthalazin-1-one |
| Synonyms | AURORA KA-6768 1-Chlorophtalazin-4-one 1-CHLOROPHTHALAZIN-4-ONE 1-CHLORO-4-PHTHALAZINONE 4-chlorophthalazin-1(2H)-one 4-CHLORO-1,2-DIHYDROPHTHALAZIN-1-ONE 4-chloro-1,2-dihydrophthalazin-1-one 1-Chloro-3,4-dihydrophthalazin-4-one |
| CAS | 2257-69-4 |
| InChI | InChI=1/C8H5ClN2O/c9-7-5-3-1-2-4-6(5)8(12)11-10-7/h1-4H,(H,11,12) |
2257-69-4 - Physico-chemical Properties
| Molecular Formula | C8H5ClN2O |
| Molar Mass | 180.59 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Melting Point | 273 °C |
| Boling Point | 452.7°C at 760 mmHg |
| Flash Point | 227.6°C |
| Vapor Presure | 8.2E-09mmHg at 25°C |
| pKa | 10.58±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.688 |
| MDL | MFCD00102192 |
2257-69-4 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
2257-69-4 - Introduction
4-chloro-1,2-dihydrophthalazin-1-one is an organic compound with the chemical formula C8H5ClN2O. The following is a description of its nature, use, formulation and safety information:
Nature:
- 4-chloro-1, 2-dihydrothalazin-1-one is a colorless crystal or a white crystalline powder.
-It has better solubility in anhydrous ethanol and dichloromethane, but has lower solubility in water.
-It has strong oxidation.
Use:
- 4-chloro-1, 2-dihydrothalazin-1-one is commonly used as an intermediate in organic synthesis.
-It can be used to synthesize biologically active compounds, drugs and dyes.
Method:
- 4-chloro-1, 2-dihydrothalazin-1-one can be prepared by the reaction of phenol and sodium nitrite, and then chlorinated.
-The specific steps of the reaction are as follows: First, phenol and sodium nitrite react under acidic conditions to produce nitrosophenol, and then chlorinate with chlorine to produce 4-chloro-1, 2-dihydroxyalazin-1-one.
Safety Information:
- 4-chloro-1, 2-dihydrothalazin-1-one should pay attention to protective measures during operation and avoid contact with skin, eyes and respiratory tract.
-It may cause irritation and damage to the eyes, skin and respiratory system, so wear appropriate protective equipment when using.
-During use or storage, care should be taken to prevent ignition and avoid contact with oxidants.
Please note that the use and operation of 4-chloro-1, 2-dihydrothalazin-1-one should follow appropriate chemical laboratory safety regulations. Use caution in the use and handling of chemical substances and comply with relevant laws and regulations.
Nature:
- 4-chloro-1, 2-dihydrothalazin-1-one is a colorless crystal or a white crystalline powder.
-It has better solubility in anhydrous ethanol and dichloromethane, but has lower solubility in water.
-It has strong oxidation.
Use:
- 4-chloro-1, 2-dihydrothalazin-1-one is commonly used as an intermediate in organic synthesis.
-It can be used to synthesize biologically active compounds, drugs and dyes.
Method:
- 4-chloro-1, 2-dihydrothalazin-1-one can be prepared by the reaction of phenol and sodium nitrite, and then chlorinated.
-The specific steps of the reaction are as follows: First, phenol and sodium nitrite react under acidic conditions to produce nitrosophenol, and then chlorinate with chlorine to produce 4-chloro-1, 2-dihydroxyalazin-1-one.
Safety Information:
- 4-chloro-1, 2-dihydrothalazin-1-one should pay attention to protective measures during operation and avoid contact with skin, eyes and respiratory tract.
-It may cause irritation and damage to the eyes, skin and respiratory system, so wear appropriate protective equipment when using.
-During use or storage, care should be taken to prevent ignition and avoid contact with oxidants.
Please note that the use and operation of 4-chloro-1, 2-dihydrothalazin-1-one should follow appropriate chemical laboratory safety regulations. Use caution in the use and handling of chemical substances and comply with relevant laws and regulations.
Last Update：2024-04-09 21:01:54
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2257-69-4
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2234-97-1
2305345-75-7
77060-74-3
54256-41-6
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73058-37-4
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131052-46-5
2234-97-1
2305345-75-7
77060-74-3
54256-41-6
10487-71-5
73058-37-4
149703-84-4
274693-25-3