23052-81-5
(2S)-2-amino-4-phosphonobutanoic acid
CAS: 23052-81-5
Molecular Formula: C4H10NO5P
23052-81-5 - Names and Identifiers
| Name | (2S)-2-amino-4-phosphonobutanoic acid |
| Synonyms | L-AP4 (S)-4-Phosphono-2-aminobutyric acid (S)-4-Phosphono-2-aminobutanoic acid (2S)-2-Amino-4-phosphonobutyric acid (2S)-2-amino-4-phosphonobutanoic acid L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID L(+)-2-AMINO-4-PHOSPHONOBUTANOIC ACID L-(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID (L-AP4) |
| CAS | 23052-81-5 |
| EINECS | 200-258-5 |
| InChI | InChI=1/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1 |
23052-81-5 - Physico-chemical Properties
| Molecular Formula | C4H10NO5P |
| Molar Mass | 183.1 |
| Density | 1.628±0.06 g/cm3(Predicted) |
| Melting Point | 207-215 °C |
| Boling Point | 491.7±55.0 °C(Predicted) |
| Flash Point | 251.2°C |
| Water Solubility | Soluble to 5 mM in water and to 100 mM in 1eq. NaOH |
| Vapor Presure | 5.18E-11mmHg at 25°C |
| Appearance | solid |
| pKa | 2.19±0.10(Predicted) |
| Storage Condition | 0-6°C |
| Sensitive | Light Sensitive |
| Refractive Index | 1.545 |
| In vivo study | Paw withdrawal threshold in response to application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks. Intrathecal injection of 5 to 30 μg of L-APB significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration. |
23052-81-5 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| RTECS | ES7191700 |
23052-81-5 - Reference Information
| biological activity | L-APB is an effective, specific agonist of metabotropic glutamate receptor (mGluR), and its EC50 values for mGlu4, mGlu8, mGlu6 and mGlu7 receptors are 0.13, 0.29, 1.0, 249 μM respectively. |
| target | mGlu 4 0.13 μ m (EC 50 ) mGlu8 0.29 μ m (EC 50) mGlu6 1.0 μ m (EC 50 ) mGlu7 249 μ m (EC 50 ) |
| in vivo study | Paw withdrawal threshold in response to application of von Frey filaments before spinal nerve ligation is 22.6±2.4g. The mechanical threshold decreases significantly (2.3±0.5g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks. Intrathecal injection of 5 to 30 μg of L-APB significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration. |
Last Update：2024-04-09 21:11:58
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