24159-07-7
Febrifugine
CAS: 24159-07-7
Molecular Formula: C16H19N3O3
24159-07-7 - Names and Identifiers
24159-07-7 - Physico-chemical Properties
| Molecular Formula | C16H19N3O3 |
| Molar Mass | 301.34 |
| Density | 1.39 |
| Melting Point | 139-140°; mp 154-156° |
| Boling Point | 508.2±60.0 °C(Predicted) |
| Specific Rotation(α) | D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol) |
| Solubility | Soluble in methanol, ethanol, DMSO and other organic solvents. |
| Appearance | White powder |
| pKa | 14.61±0.40(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD01685990 |
| Physical and Chemical Properties | Soluble in organic solvents such as methanol, ethanol, DMSO, etc., from Changshan. |
24159-07-7 - Risk and Safety
| Toxicity | LD50 orally in white mice: 2.5-3.0 mg/kg (Koepfli, 1949) |
24159-07-7 - Reference
| Reference Show more | 1. [IF=5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement."Arab J Chem. 2022 Jun;15:103825 |
24159-07-7 - Reference Information
| product description | Changshan is the dry root of the Saxifraga plant Changshan, which is mainly used to treat malaria. "Shen Nong's Materia Medica" records that Changshan has the effects of vomiting, insecticidal, anti-malaria, and antipyretic. In recent years, the related research of Changshonine is still paid attention by scholars at home and abroad, such as the structural modification, chemical synthesis, anti-tumor, anti-coccidia, anti-scar, etc. |
| biological activity | Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Changshan, with antimalarial activity. |
| Chemical properties | Soluble in organic solvents such as methanol, ethanol, DMSO, etc., from Changshan. |
| use | changshan B has antiarrhythmic effect. used for content determination/identification/pharmacological experiment, etc. |
Last Update：2024-04-09 20:49:11
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