24485-01-6
5,7-dichloro-7aH-imidazo[4,5-b]pyridine
CAS: 24485-01-6
Molecular Formula: C6H3Cl2N3
24485-01-6 - Names and Identifiers
24485-01-6 - Physico-chemical Properties
| Molecular Formula | C6H3Cl2N3 |
| Molar Mass | 188.01 |
| Density | 1.79±0.1 g/cm3(Predicted) |
| Melting Point | 273-274 °C |
| Boling Point | 200.8±50.0 °C(Predicted) |
| Flash Point | 119.4°C |
| Vapor Presure | 0.00936mmHg at 25°C |
| pKa | 5.37±0.40(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.768 |
24485-01-6 - Introduction
5,7-dichloro-7ah-imidazo [4,5-b]pyridine is an organic compound with the chemical formula C8H4Cl2N2. The following is a description of its nature, use, formulation and safety information:
Nature:
-Appearance: White or light yellow crystal powder
-Melting Point: about 176-179 ℃
-Boiling point: About 358-359 ℃
-Solubility: Slightly soluble in ethanol, insoluble in water
Use:
-As an intermediate in organic synthesis, it is widely used in the synthesis of other organic compounds and drugs.
-Can be used to synthesize biologically active compounds, such as anti-tumor agents.
Method:
5,7-dichloro-7ah-imidazo [4,5-b]pyridine can be prepared in many ways. The following is one of the common methods:
1.5-chloropyridine and O-nitrobenzene naphthalene are reacted in a mixed acid of sulfuric acid and nitric acid to generate 7-nitro -5-chloropyridine.
2. The 7-nitro-5-chloropyridine is reacted with sulfuric acid and sodium nitrite in an ice bath to obtain 5,7-dichloropyridine.
3. Finally, 5,7-dichloropyridine and urea are cyclized in dimethyl sulfoxide to generate 5,7-dichloro-7ah-imidazo [4,5-b]pyridine.
Safety Information:
-5,7-dichloro-7ah-imidazo [4,5-b]pyridine is an organic compound with certain toxicity and irritation.
-Wear appropriate protective equipment such as lab gloves, goggles and protective clothing when used.
-Avoid contact with skin, eyes and respiratory tract.
-Ensure good ventilation during operation.
-Avoid contact with strong oxidants during storage.
-Before use and handling, carefully read and follow the relevant safety instructions and operating procedures.
Nature:
-Appearance: White or light yellow crystal powder
-Melting Point: about 176-179 ℃
-Boiling point: About 358-359 ℃
-Solubility: Slightly soluble in ethanol, insoluble in water
Use:
-As an intermediate in organic synthesis, it is widely used in the synthesis of other organic compounds and drugs.
-Can be used to synthesize biologically active compounds, such as anti-tumor agents.
Method:
5,7-dichloro-7ah-imidazo [4,5-b]pyridine can be prepared in many ways. The following is one of the common methods:
1.5-chloropyridine and O-nitrobenzene naphthalene are reacted in a mixed acid of sulfuric acid and nitric acid to generate 7-nitro -5-chloropyridine.
2. The 7-nitro-5-chloropyridine is reacted with sulfuric acid and sodium nitrite in an ice bath to obtain 5,7-dichloropyridine.
3. Finally, 5,7-dichloropyridine and urea are cyclized in dimethyl sulfoxide to generate 5,7-dichloro-7ah-imidazo [4,5-b]pyridine.
Safety Information:
-5,7-dichloro-7ah-imidazo [4,5-b]pyridine is an organic compound with certain toxicity and irritation.
-Wear appropriate protective equipment such as lab gloves, goggles and protective clothing when used.
-Avoid contact with skin, eyes and respiratory tract.
-Ensure good ventilation during operation.
-Avoid contact with strong oxidants during storage.
-Before use and handling, carefully read and follow the relevant safety instructions and operating procedures.
Last Update：2024-04-09 21:00:56
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