251997-31-6
2,3,5-Trichloropyridine-4-carboxaldehyde
CAS: 251997-31-6
Molecular Formula: C6H2Cl3NO
251997-31-6 - Names and Identifiers
251997-31-6 - Physico-chemical Properties
| Molecular Formula | C6H2Cl3NO |
| Molar Mass | 210.45 |
| Density | 1.616±0.06 g/cm3(Predicted) |
| Boling Point | 274.0±35.0 °C(Predicted) |
| Flash Point | 119.5°C |
| Vapor Presure | 0.00556mmHg at 25°C |
| pKa | -4.25±0.10(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.62 |
| MDL | MFCD06410668 |
251997-31-6 - Reference Information
| Application | 2,3, 5-trichloro-4-pyridine formaldehyde can be used as an intermediate in organic synthesis, which can be prepared by reacting with methyl formate under the action of lithium diisopropyl amide. |
| preparation | nitrogen protection, at -78°C, 20ml of 2,3, 5-trichloropyridine (2g,11mmol) solution of tetrahydrofuran was added to lithium diisopropylamide (7.3mL,1.5M cyclohexane, 11mmol) in 10mL of anhydrous THF solution and stirred for another 30 minutes, methyl formate (1.4mL,1.3g,22mmol) dissolved in 14mL THF was then slowly added to the brown solution within 15 minutes, allowing it to slowly heat up to room temperature and stir overnight. The resulting dark brown solution was poured on ice and saturated NaHCO3, extracted with ethyl acetate, washed with brine, dried (Na2SO4) and concentrated. The brown oil was purified by silica gel rapid chromatography and eluted with 20-33% ethyl acetate/hexane to obtain 2,3, 5-trichloro-4-pyridine formaldehyde in yield:(1.7g,74%). |
Last Update：2024-04-09 20:52:54
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