2566-44-1
2-Cyclopropylethanol
CAS: 2566-44-1
Molecular Formula: C5H10O
2566-44-1 - Names and Identifiers
| Name | 2-Cyclopropylethanol |
| Synonyms | Cyclopropaneethanol 2-CYCLOPROPYLETHANOL 2-Cyclopropylethanol 2-Cyclopropylethan-1-ol (2-Hydroxyethyl)cyclopropane Cyclopropaneethanol~(2-Hydroxyethyl)cyclopropane |
| CAS | 2566-44-1 |
| EINECS | 680-717-9 |
| InChI | InChI=1/C5H10O/c6-4-3-5-1-2-5/h5-6H,1-4H2 |
2566-44-1 - Physico-chemical Properties
| Molecular Formula | C5H10O |
| Molar Mass | 86.13 |
| Density | 0.975±0.06 g/cm3(Predicted) |
| Boling Point | 137-138°C |
| Flash Point | 47°C |
| Water Solubility | Miscible with water. |
| Solubility | Chloroform, Methanol |
| Vapor Presure | 5.13mmHg at 25°C |
| Appearance | Oil |
| Color | Clear Colorless |
| BRN | 2036028 |
| pKa | 15.16±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.4355 |
| MDL | MFCD00040762 |
2566-44-1 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R10 - Flammable R36 - Irritating to the eyes R22 - Harmful if swallowed |
| Safety Description | S16 - Keep away from sources of ignition. S23 - Do not breathe vapour. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 1987 |
| Hazard Class | 3 |
| Packing Group | III |
2566-44-1 - Reference Information
| application | cyclopropyl ethanol is a pharmaceutical intermediate, which can be reduced by esterification of cyclopropyl acetic acid Get. There are reports that cyclopropanol can be used to prepare inhibitors of human immunodeficiency virus replication. |
| preparing | step 1. preparation of methyl cyclopropyl acetate dissolves cyclopropyl acetic acid (1.08g;10.57 mmol) in 50 ml of methanol. The solution was cooled to 0°C and 5ml of 96% sulfuric acid was added dropwise under stirring. The solution was kept overnight at room temperature, then poured into ice water, alkalized with ammonium 30% hydrate, and finally extracted with dichloromethane. The organic layer is dried by sodium sulfate and evaporated to dryness to give 1.1g of oily product (90% yield), which can be used as such without further purification. Step 2. preparation of cyclopropyl ethanol sodium (85 mg;0.004 mmol) was dissolved in 50 ml of methanol, and then 8.7g(0.23 mol) of sodium borohydride was added. A solution of 3.7g(0.032mol) of cyclopropylmethyl acetate prepared according to step 1 in 20ml of methanol was added dropwise to the mixture under stirring. The reaction was kept under reflux for 6 hours, then 300ml of saline was added and the crude product was extracted with dichloromethane. The organic layer was dried with sodium sulfate and evaporated to dryness to obtain 1.52g(55% yield) of the title compound. |
Last Update：2024-04-10 22:29:15
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