28314-81-0
3-bromo-2,6-difluorobenzoic acid
CAS: 28314-81-0
Molecular Formula: C7H3BrF2O2
28314-81-0 - Names and Identifiers
| Name | 3-bromo-2,6-difluorobenzoic acid |
| Synonyms | 3-bromo-2,6-difluorobenzoic acid Benzoic acid, 3-broMo-2,6-difluoro- |
| CAS | 28314-81-0 |
| InChI | InChI=1/C7H3BrF2O2/c8-3-1-2-4(9)5(6(3)10)7(11)12/h1-2H,(H,11,12) |
28314-81-0 - Physico-chemical Properties
| Molecular Formula | C7H3BrF2O2 |
| Molar Mass | 237.00 |
| Density | 1.872g/cm3 |
| Melting Point | 137-139℃ |
| Boling Point | 279.2°C at 760 mmHg |
| Flash Point | 122.7°C |
| Vapor Presure | 0.00194mmHg at 25°C |
| Storage Condition | Room Temprature |
| Refractive Index | 1.558 |
| Use | Use 3-bromo-2, 6-difluorobenzoic acid can be used as an intermediate in the synthesis of medicine. |
28314-81-0 - Upstream Downstream Industry
| Raw Materials | 2,4-Difluorobenzoic acid 1-Bromo-2,4-difluorobenzene 1-Bromo-2,6-difluorobenzene 2,6-Difluorobenzoic acid CARBON DIOXIDE 1,3-Difluorobenzene |
28314-81-0 - Preparation
3-bromo-2, 6-difluorobenzoic acid can be prepared from 1-bromo-2, 4-difluorobenzene as the reaction raw material and reacted with carbon dioxide to prepare another intermediate 3-bromo-2, 6-difluorophenylcarbamate tert-butyl ester.
Preparation of 3-bromo-2, 6-difluorobenzoic acid: Diisopropylamine (8.1mL,57.0mmol) and THF(260mL) were added to the dried 2-neck round bottom flask under argon at room temperature. The solution was cooled to -70°C in a dry ice-acetone bath. Drop addition of n-butyllithium (2.0M in cyclohexane, 25.9mL,51.8mmol) through a syringe, the resulting reaction was briefly warmed to 0°C, and then cooled back to -70°C. Drop 1-bromo -2, 4-difluorobenzene (5.9mL,52.0mmol) to the cold solution through a syringe. After adding, the reaction was kept at -70°C for 1 hour. Add carbon dioxide (5-9g tablets, rinse with dry THF in advance) to the solution. Remove the Ar bladders and replace them with bubblers to allow venting. The resulting reaction was then warmed to room temperature and quenched to pH-7-8 with a saturated NH4Cl aqueous solution. The aqueous mixture was washed with EtOAc, acidified to pH-2-3 with 6NHCl aqueous solution, and extracted with EtOAc. The organic extract was washed with brine, dried (Na2SO4), filtered, and concentrated under vacuum to obtain 10.9g(89%) 3-bromo-2, 6-difluorobenzoic acid: 1HNMR(400MHz,DMSO-d6)& delta;7.25(m,1H)7.92(m,1H).
Last Update：2024-04-10 22:29:15
Supplier List
Featured ProductsSpot supply
Product Name: 3-Bromo-2,6-difluorobenzoic acid Visit Supplier Webpage Request for quotationCAS: 28314-81-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 3-Bromo-2,6-difluorobenzoic acid Request for quotationCAS: 28314-81-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 3-bromo-2,6-difluorobenzoic acid Visit Supplier Webpage Request for quotationCAS: 28314-81-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: 3-Bromo-2,6-Difluorobenzoic Acid Visit Supplier Webpage Request for quotation
CAS: 28314-81-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 28314-81-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: 3-Bromo-2,6-difluorobenzoic acid Visit Supplier Webpage Request for quotationCAS: 28314-81-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 3-Bromo-2,6-difluorobenzoic acid Request for quotationCAS: 28314-81-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 3-bromo-2,6-difluorobenzoic acid Visit Supplier Webpage Request for quotationCAS: 28314-81-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: 3-Bromo-2,6-Difluorobenzoic Acid Visit Supplier Webpage Request for quotation
CAS: 28314-81-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 28314-81-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
28314-81-0
META(R)METALDEHYDE
16947-80-1
85700-55-6
952514-79-3
18171-14-7
p-Pentyloxybenzaldehyde
103394-76-9
32454-27-6
Imipramine hydrochloride
META(R)METALDEHYDE
16947-80-1
85700-55-6
952514-79-3
18171-14-7
p-Pentyloxybenzaldehyde
103394-76-9
32454-27-6
Imipramine hydrochloride
Raw Materials for 28314-81-0
2,4-Difluorobenzoic acid
1-Bromo-2,4-difluorobenzene
1-Bromo-2,6-difluorobenzene
2,6-Difluorobenzoic acid
CARBON DIOXIDE
1,3-Difluorobenzene
1-Bromo-2,4-difluorobenzene
1-Bromo-2,6-difluorobenzene
2,6-Difluorobenzoic acid
CARBON DIOXIDE
1,3-Difluorobenzene