290835-85-7
2,6-Dichloro-3-Fluoro Acetophenone
CAS: 290835-85-7
Molecular Formula: C8H5Cl2FO
290835-85-7 - Names and Identifiers
| Name | 2,6-Dichloro-3-Fluoro Acetophenone |
| Synonyms | 2,6-DICHLORO-3-FLUOROACETOPHENONE 3-Fluoro-2,6-Dichloroacetophenone 2,6-Dichloro-3-Fluoroacetophenone 2,6-dichloro-3-fluro acetophenone 2,6-Dichloro-3-Fluoro Acetophenone 2,6-DICHLORO-5-FLUORO ACETOPHENONE 2',6'-DICHLORO-3'-FLUOROACETOPHENONE 2',6'-Dichloro-3'-fluoroacetophenone 2',6'-DICHLORO-3'-FLUOROACETOPHENONE, 98 2',6'-Dichloro-3'-Fluoroacetophenone 3-Fluoro-2,6-Dichloroacetophenone |
| CAS | 290835-85-7 |
| InChI | InChI=1/C8H5Cl2FO/c1-4(12)7-5(9)2-3-6(11)8(7)10/h2-3H,1H3 |
| InChIKey | VJBFZHHRVCPAPZ-UHFFFAOYSA-N |
290835-85-7 - Physico-chemical Properties
| Molecular Formula | C8H5Cl2FO |
| Molar Mass | 207.03 |
| Density | 1.403g/mLat 25°C(lit.) |
| Boling Point | 255°C(lit.) |
| Flash Point | 255°C |
| Vapor Presure | 0.143mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.403 |
| Color | Clear colorless to light yellow |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.529(lit.) |
290835-85-7 - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed R25 - Toxic if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2810 6.1/PG 3 |
| WGK Germany | 3 |
| HS Code | 29143990 |
| Hazard Note | Flammable |
| Hazard Class | IRRITANT |
| Packing Group | III |
290835-85-7 - Reference Information
| introduction | 2,6-dichloro -3-fluoroacetophenone is anhydrous or light yellow liquid at normal temperature and pressure. it belongs to acetophenone derivatives, insoluble in water, soluble in most organic solvents, used to make cigarettes, and also used as intermediates in organic chemical synthesis, fiber resins and plasticizers for plastics. |
| Uses | 2, 6-dichloro-3-fluoroacetophenone can be used as an intermediate in pharmaceutical chemistry and organic synthesis. In the synthesis and transformation, the ketone unit in the structure can be easily reduced to alcohol, become olefin through wittig reaction, and can also become acid or ester through oxidation reaction. |
| synthesis method | 1-(2, 6-dichloro-3-fluorophenyl) ethanol (1 mmol), zinc bromide (45 mg, 0.2 mmol) and chloramine (282 mg, 1 mmol) acetonitrile solution into a three-neck flask with a reflux condenser, stir the mixture under reflux for 5 hours and cool to room temperature. First slowly add water to quench the reaction system, then extract the obtained mixture three times with ethyl acetate, combine the extracted organic solvent, dry the obtained organic layer with anhydrous sodium sulfate, filter to remove the sodium sulfate solid, and the obtained filtrate is evaporated under reduced pressure to remove the solvent to obtain the crude product, and the target product 2, 6-dichloro-3-fluoroacetophenone can be obtained by purifying the residue through silica gel column chromatography. Fig. 2, synthetic route of 6-dichloro-3-fluoroacetophenone |
Last Update：2024-04-10 22:29:15
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