3-BroMo-1-Methyl-pyrrolidine
3-BroMo-1-Methyl-pyrrolidine
CAS: 10603-45-9
Molecular Formula: C5H10BrN
3-BroMo-1-Methyl-pyrrolidine - Names and Identifiers
| Name | 3-BroMo-1-Methyl-pyrrolidine |
| Synonyms | 3-BroMo-1-Methyl-pyrrolidine Pyrrolidine, 3-bromo-1-methyl- |
| CAS | 10603-45-9 |
3-BroMo-1-Methyl-pyrrolidine - Physico-chemical Properties
| Molecular Formula | C5H10BrN |
| Molar Mass | 164.04 |
| Density | 1.361 g/mL at 25 °C |
| Boling Point | 153-159 °C |
| Flash Point | 54 °C |
| Appearance | Liquid |
| Color | Yellow to brown |
| pKa | 8.53±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.4910 |
| MDL | MFCD12755877 |
| Use | 3-Bromo-1-methylpyrrolidine is a colorless liquid and an important pharmaceutical intermediate raw material. 3-Bromo-1-methylpyrrolidine can be used to prepare mGluR5 receptor allosteric modulators. |
3-BroMo-1-Methyl-pyrrolidine - Risk and Safety
| Risk Codes | R11 - Highly Flammable R34 - Causes burns |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2924 8(3) / PGIII |
| Hazard Class | 3 |
| Packing Group | Ⅲ |
3-BroMo-1-Methyl-pyrrolidine - Preparation
3-hydroxy -1-methyl pyrrolidine (5g) was added to a 100ml single-mouth bottle, n-hexane (50ml) was cooled in an ice bath for 10min, phosphorus tribromide (16.9g) was added under cooling, and the temperature was raised to reflux for 2h. Cooling. Add 25% KOH and neutralize until pH>8. Ether extraction. Combined organic phase, add 1N hydrochloric acid 50ml, extraction. Retain the aqueous phase, adjust pH>8, ether extraction. Air dry. 3-bromo-1-methyl pyrrolidine (1.1g).
Last Update：2024-04-10 22:29:15
3-BroMo-1-Methyl-pyrrolidine - Reference Information
| application | 3-brom-1-methylpyrrolidine is a colorless liquid and an important pharmaceutical intermediate raw material. 3-Bromo-1-methylpyrrolidine can be used to prepare mGluR5 receptor allosteric modulators. |
| preparation | 3-hydroxy -1-methylpyrrolidine (5g) was added into a 100ml single-mouth bottle, n-hexane (50ml) was cooled in an ice bath for 10min, phosphorus tribromide (16.9g) was added under cooling, and the temperature was raised to reflux for 2h. Cooling. Add 25% KOH and neutralize until pH>8. Ether extraction. Combined organic phase, add 1N hydrochloric acid 50ml, extraction. Retain the aqueous phase, adjust pH>8, ether extraction. Air dry. 3-bromo-1-methyl pyrrolidine (1.1g). |
Last Update：2024-04-09 02:00:03
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