3-CHLORO-5-METHYLPYRIDINE
3-CHLORO-5-METHYLPYRIDINE
CAS: 19230-55-8
Molecular Formula: C6H6ClN
3-CHLORO-5-METHYLPYRIDINE - Names and Identifiers
| Name | 3-CHLORO-5-METHYLPYRIDINE |
| Synonyms | 5-CHLORO-3-PICOLINE 3-CHLORO-5-METHYLPYRIDINE Pyridine, 3-chloro-5-methyl- |
| CAS | 19230-55-8 |
| EINECS | 807-927-7 |
| InChI | InChI=1/C6H6ClN/c1-5-2-6(7)4-8-3-5/h2-4H,1H3 |
3-CHLORO-5-METHYLPYRIDINE - Physico-chemical Properties
| Molecular Formula | C6H6ClN |
| Molar Mass | 127.57 |
| Density | 1.150±0.06 g/cm3(Predicted) |
| Boling Point | 176.7±20.0 °C(Predicted) |
| Flash Point | 75.7°C |
| Vapor Presure | 1.45mmHg at 25°C |
| pKa | 3.24±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.526 |
3-CHLORO-5-METHYLPYRIDINE - Introduction
3-chloro-5-methylpyriridine is an organic compound with the chemical formula C6H6ClN. The following is a description of the properties, uses, preparation and safety information of 3-chloro-5-methylpyriridine:
Nature:
-Appearance: 3-chloro-5-methylpyriridine is a colorless to yellow liquid.
-Solubility: Can be dissolved in most organic solvents, insoluble in water.
-Odor: has a special aromatic smell.
Use:
- 3-CHLORO-5-METHYLPYRIDINE is commonly used as a pharmaceutical intermediate and has important applications in the synthesis of pharmaceuticals and pesticides.
-It can also be used as a catalyst and solvent, as well as a reagent in certain chemical reactions.
Method:
The preparation of 3-CHLORO-5-METHYLPYRIDINE can be completed by the following steps:
1. From 2-methylpyridine, chlorination reaction is carried out under alkaline conditions to chlorinate the methyl group in 2-methylpyridine to 3-chloro-2-methylpyridine.
2. A chlorination reaction was further carried out under acidic conditions to chlorinate the 2-position methyl group in 3-chloro-2-methylpyridine to 3-chloroo-5-methylpyrridine.
Safety Information:
- 3-CHLORO-5-METHYLPYRIDINE is irritating and corrosive and should be handled carefully to avoid contact with skin and eyes.
-Use with chemical protective gloves, goggles and protective clothing.
-In case of contact, rinse immediately with plenty of water and seek medical help.
-In storage and handling, to follow the chemical safety procedures, and store it in a cool, dry, well-ventilated place, away from fire and flammable materials.
Nature:
-Appearance: 3-chloro-5-methylpyriridine is a colorless to yellow liquid.
-Solubility: Can be dissolved in most organic solvents, insoluble in water.
-Odor: has a special aromatic smell.
Use:
- 3-CHLORO-5-METHYLPYRIDINE is commonly used as a pharmaceutical intermediate and has important applications in the synthesis of pharmaceuticals and pesticides.
-It can also be used as a catalyst and solvent, as well as a reagent in certain chemical reactions.
Method:
The preparation of 3-CHLORO-5-METHYLPYRIDINE can be completed by the following steps:
1. From 2-methylpyridine, chlorination reaction is carried out under alkaline conditions to chlorinate the methyl group in 2-methylpyridine to 3-chloro-2-methylpyridine.
2. A chlorination reaction was further carried out under acidic conditions to chlorinate the 2-position methyl group in 3-chloro-2-methylpyridine to 3-chloroo-5-methylpyrridine.
Safety Information:
- 3-CHLORO-5-METHYLPYRIDINE is irritating and corrosive and should be handled carefully to avoid contact with skin and eyes.
-Use with chemical protective gloves, goggles and protective clothing.
-In case of contact, rinse immediately with plenty of water and seek medical help.
-In storage and handling, to follow the chemical safety procedures, and store it in a cool, dry, well-ventilated place, away from fire and flammable materials.
Last Update：2024-04-09 15:17:54
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