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3-Chloro-2-fluoro-pyridine

3-Chloro-2-fluoro-pyridine

CAS: 1480-64-4

Molecular Formula: C5H3ClFN

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3-Chloro-2-fluoro-pyridine - Names and Identifiers

Name 3-Chloro-2-fluoro-pyridine
Synonyms 3-CHLORO-2-FLUOROPYRIDINE
3-Chloro-2-fluoro-pyridine
2-Fluoro-3-chloro pyridine
Pyridine, 3-chloro-2-fluoro-
CAS 1480-64-4
InChI InChI=1/C5H3ClFN/c6-4-2-1-3-8-5(4)7/h1-3H
InChIKey IHGMHTQDGNVKTA-UHFFFAOYSA-N

3-Chloro-2-fluoro-pyridine - Physico-chemical Properties

Molecular FormulaC5H3ClFN
Molar Mass131.54
Density1.33
Boling Point162℃
Flash Point52°(126°F)
Vapor Presure2.86mmHg at 25°C
Appearanceclear liquid
ColorColorless to Almost colorless
pKa-2.71±0.10(Predicted)
Storage Conditionunder inert gas (nitrogen or Argon) at 2-8°C
Refractive Index1.5030

3-Chloro-2-fluoro-pyridine - Risk and Safety

Risk CodesR22 - Harmful if swallowed
R37/38 - Irritating to respiratory system and skin.
R41 - Risk of serious damage to eyes
R34 - Causes burns
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R10 - Flammable
Safety DescriptionS26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S39 - Wear eye / face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs2924
HS Code29333990
Hazard Class3
Packing GroupIII

3-Chloro-2-fluoro-pyridine - Reference Information

Application 3-chloro-2-fluoropyridine is an organic intermediate, it can be obtained from 2-nitro-3-chloropyridine or 2, 3-dichloropyridine by fluoro in one step. 3-chloro-2-fluoropyridine can be used for the preparation of 3-chloro-2 hydrazopyridine. 3-chloro-2-hydrazinopyridine is an important intermediate for the synthesis of a new type of receiver insecticide, chlorfenamide and cyanuramide.
preparation cesium fluoride (2.053g,13.51 mmol) was added to 2, 3-dichloropyridine (1.00g,6.76 mmol) in dimethyl sulfoxide (33.8
ml). The mixture was stirred at 110°C for 20 h in air. The mixture was quenched with water at room temperature. The reaction mixture was extracted with EtOAc. The organic layer was separated. The organic layer was washed with water and brine. The organic layer was dried over anhydrous sodium sulfate. The organic layer was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluting with ethyl acetate in hexane) to give 3-chloro-2-fluoropyridine.
Last Update:2024-04-09 20:48:19
3-Chloro-2-fluoro-pyridine
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