300586-90-7
OAC1
CAS: 300586-90-7
Molecular Formula: C14H11N3O
300586-90-7 - Names and Identifiers
300586-90-7 - Physico-chemical Properties
| Molecular Formula | C14H11N3O |
| Molar Mass | 237.26 |
| Density | 1.363±0.06 g/cm3(Predicted) |
| Boling Point | 386.6±22.0 °C(Predicted) |
| Solubility | DMSO: soluble20mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| pKa | 11.76±0.43(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | 1 μm OAC1 increases reprogramming efficiency by activating the luciferase reporter gene driven by the Oct4 and Nanog promoters. In addition, OAC1 acts on mouse embryonic fibroblasts (MEFs) treated with four kinds of reprogramming factors (Oct4, Sox2, c-Myc, and Klf4) to improve the reprogramming efficiency of pluripotent stem cells (iPSCs), and accelerate the reprogramming process. Treatment of the derived iPSC community with OAC1 along with four reprogramming factors showed typical ESC morphology, gene expression patterns, and developmental potential. OAC1 improves reprogramming efficiency by enhancing transcription of the Oct4-Nanog-Sox2 triplet and Tet1, a gene known to be involved in DNA demethylation. OAC1 did not inhibit the p53-p21 pathway or activate Wnt-β-catenin signaling. OAC1 can be used to increase reprogramming of somatic pluripotent states. |
300586-90-7 - Risk and Safety
| WGK Germany | 3 |
300586-90-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.215 ml | 21.074 ml | 42.148 ml |
| 5 mM | 0.843 ml | 4.215 ml | 8.43 ml |
| 10 mM | 0.421 ml | 2.107 ml | 4.215 ml |
| 5 mM | 0.084 ml | 0.421 ml | 0.843 ml |
Last Update：2024-01-02 23:10:35
300586-90-7 - Introduction
OAC1 represents 3-(5-methylisoxazolin-3-yl) phenol. The following is a description of the nature, use, formulation and safety information of OAC1:
Properties: OAC1 is a white or off-white crystalline solid. It is an organic acid, soluble in some organic solvents, such as chloroform, dimethyl sulfoxide and methylene chloride.
Purpose: OAC1 is a commonly used pharmaceutical compound, mainly used to study autophagy in cell biology. It can inhibit the process of autophagy by blocking the activity of autophagy regulatory protein 1(ATG4B), thus affecting cell survival and apoptosis. In addition, OAC1 has also been used as an anti-tumor agent, an anti-inflammatory agent and an antiviral agent.
Preparation method: A common method for preparing OAC1 is to synthesize it through the fluorination reaction of isoxazoline. The specific steps include the reaction of isoxazoline with P-trifluoromethylbenzene alcohol, and the fluorination reaction is carried out under alkali catalysis to form oac1.
Safety information: OAC1 should be used in accordance with laboratory and chemical safety practices. It can be irritating and corrosive, and can be irritating to the eyes, skin, and respiratory system. Personal protective equipment such as lab gloves, protective glasses and protective clothing should be used when using and storing oac1. At the same time, it should be prevented from contact with strong oxidants, acids and bases to avoid possible reactions and dangers. If inhaled or exposed to OAC1, clean the affected area immediately and seek medical advice.
Properties: OAC1 is a white or off-white crystalline solid. It is an organic acid, soluble in some organic solvents, such as chloroform, dimethyl sulfoxide and methylene chloride.
Purpose: OAC1 is a commonly used pharmaceutical compound, mainly used to study autophagy in cell biology. It can inhibit the process of autophagy by blocking the activity of autophagy regulatory protein 1(ATG4B), thus affecting cell survival and apoptosis. In addition, OAC1 has also been used as an anti-tumor agent, an anti-inflammatory agent and an antiviral agent.
Preparation method: A common method for preparing OAC1 is to synthesize it through the fluorination reaction of isoxazoline. The specific steps include the reaction of isoxazoline with P-trifluoromethylbenzene alcohol, and the fluorination reaction is carried out under alkali catalysis to form oac1.
Safety information: OAC1 should be used in accordance with laboratory and chemical safety practices. It can be irritating and corrosive, and can be irritating to the eyes, skin, and respiratory system. Personal protective equipment such as lab gloves, protective glasses and protective clothing should be used when using and storing oac1. At the same time, it should be prevented from contact with strong oxidants, acids and bases to avoid possible reactions and dangers. If inhaled or exposed to OAC1, clean the affected area immediately and seek medical advice.
Last Update：2024-04-09 21:11:58
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Product Name: OAC1 Visit Supplier Webpage Request for quotationCAS: 300586-90-7
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: OAC1 Request for quotationCAS: 300586-90-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: OAC1 Visit Supplier Webpage Request for quotationCAS: 300586-90-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: OAC1 Visit Supplier Webpage Request for quotationCAS: 300586-90-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: OAC1 Visit Supplier Webpage Request for quotationCAS: 300586-90-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
300586-90-7
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171672-98-3
203302-92-5
16774-56-4
83055-99-6
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5757-66-4
266359-48-2
1243382-67-3
133868-46-9