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317318-70-0

2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid

CAS: 317318-70-0

Molecular Formula: C21H18F3NO3S2

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317318-70-0 - Names and Identifiers

Name 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid
Synonyms GW501516
GW 501516
CB6465728
GW-501615
GW-501516
Cardarine(GW501516, GSK-516)
2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a
2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid
{2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-acetic acid
Acetic acid, (2-methyl-4-(((4-methyl-2-(4-(trifluoromethyl)phenyl)-5-thiazolyl)methyl)thio)phenoxy)-
2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid
{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
CAS 317318-70-0
EINECS 1592732-453-0
InChI InChI=1/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
InChIKey YDBLKRPLXZNVNB-UHFFFAOYSA-N

317318-70-0 - Physico-chemical Properties

Molecular FormulaC21H18F3NO3S2
Molar Mass453.5
Density1.42±0.1 g/cm3(Predicted)
Melting Point134-136°C
Boling Point584.5±60.0 °C(Predicted)
Flash Point307.321°C
Solubility DMSO: soluble20mg/mL, clear
Vapor Presure0mmHg at 25°C
Appearancepowder
Colorwhite to beige
BRN18515150
pKa3.17±0.10(Predicted)
Storage Condition-20°C
StabilityLight Sensitive
Refractive Index1.619
In vitro study GW 501516 is shown to be the most potent and selective PPARα agonists known with an EC 50 of 1.1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and-γ. GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW 501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner.
In vivo study GW 501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats. GW 501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy model. GW 501516 treatment enhances running endurance and the proportion of succinate dehydrogenase (SDH)-positive muscle fibres in both trained and untrained mice.

317318-70-0 - Risk and Safety

WGK Germany3
RTECSAI9105500

317318-70-0 - Reference Information

biological activity GW 501516 (GW 1516) is an agonist of PPARδ with an EC50 value of 1.1 nM.
TargetValue
PPARδ (Cell-free assay) 1 nM(Ki)
Last Update：2024-04-09 21:01:54
317318-70-0
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CAS: 317318-70-0
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SKYRUN INDUSTRIAL CO.,LTD
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Email: sales@chinaskyrun.com
Mobile: +8618958170122
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Product Name: GW 501516 Request for quotation
CAS: 317318-70-0
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