Molecular Formula | C110H192N40O24S4 |
Molar Mass | 2587.24 |
Density | 1.50±0.1 g/cm3(Predicted) |
Storage Condition | −20°C |
MDL | MFCD00167557 |
In vivo study | Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125 I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents. |
WGK Germany | 3 |
RTECS | OQ5980000 |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 0.387 ml | 1.933 ml | 3.865 ml |
5 mM | 0.077 ml | 0.387 ml | 0.773 ml |
10 mM | 0.039 ml | 0.193 ml | 0.387 ml |
5 mM | 0.008 ml | 0.039 ml | 0.077 ml |