32908-73-9
Mast Cell Degranulating Peptide
CAS: 32908-73-9
Molecular Formula: C110H192N40O24S4
32908-73-9 - Names and Identifiers
32908-73-9 - Physico-chemical Properties
| Molecular Formula | C110H192N40O24S4 |
| Molar Mass | 2587.24 |
| Density | 1.50±0.1 g/cm3(Predicted) |
| Storage Condition | −20°C |
| MDL | MFCD00167557 |
| In vivo study | Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125 I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, i.e., hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcutaneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5- hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents. |
32908-73-9 - Risk and Safety
| WGK Germany | 3 |
| RTECS | OQ5980000 |
32908-73-9 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0.387 ml | 1.933 ml | 3.865 ml |
| 5 mM | 0.077 ml | 0.387 ml | 0.773 ml |
| 10 mM | 0.039 ml | 0.193 ml | 0.387 ml |
| 5 mM | 0.008 ml | 0.039 ml | 0.077 ml |
Last Update：2024-01-02 23:10:35
32908-73-9 - Introduction
Mast Cell Degranulating Peptide(MCDP) is a kind of Peptide Substance with some special properties. MCDP can cause mast cell degranulation and release bioactive substances, such as histamine and interleukin. It can trigger cell degranulation by binding to receptors on mast cells.
One of the main uses of MCDP is to study the function of mast cells and inflammatory processes. It is widely used in cytology, immunology and pharmacology in the laboratory. By studying the mechanism of MCDP, we can further understand the pathogenesis of mast cell related diseases and explore new therapeutic strategies.
The method of preparing MCDP is mainly obtained by chemical synthesis or genetic engineering technology. Chemical synthetic methods usually involve the stepwise synthesis of the amino acid sequence and the use of appropriate protecting groups and deprotection methods to finally obtain the complete MCDP. Genetic engineering techniques are prepared by biosynthesis by expressing the gene encoding MCDP in a suitable host.
when using MCDP, it is necessary to follow the corresponding experimental operation specifications to ensure safety. It is a biologically active substance with certain toxicity and irritation and requires careful handling. Appropriate protective measures, such as wearing gloves, goggles and other personal protective equipment, should be taken to avoid direct contact when conducting relevant experiments.
In addition, the stability of MCDP also needs to be considered, which may be affected by environmental factors such as temperature and pH. During storage and use, care should be taken to avoid exposure to adverse conditions to maintain its activity.
One of the main uses of MCDP is to study the function of mast cells and inflammatory processes. It is widely used in cytology, immunology and pharmacology in the laboratory. By studying the mechanism of MCDP, we can further understand the pathogenesis of mast cell related diseases and explore new therapeutic strategies.
The method of preparing MCDP is mainly obtained by chemical synthesis or genetic engineering technology. Chemical synthetic methods usually involve the stepwise synthesis of the amino acid sequence and the use of appropriate protecting groups and deprotection methods to finally obtain the complete MCDP. Genetic engineering techniques are prepared by biosynthesis by expressing the gene encoding MCDP in a suitable host.
when using MCDP, it is necessary to follow the corresponding experimental operation specifications to ensure safety. It is a biologically active substance with certain toxicity and irritation and requires careful handling. Appropriate protective measures, such as wearing gloves, goggles and other personal protective equipment, should be taken to avoid direct contact when conducting relevant experiments.
In addition, the stability of MCDP also needs to be considered, which may be affected by environmental factors such as temperature and pH. During storage and use, care should be taken to avoid exposure to adverse conditions to maintain its activity.
Last Update：2024-04-09 20:52:54
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CAS: 32908-73-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Peptide 401 Request for quotationCAS: 32908-73-9
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Peptide 401 Visit Supplier Webpage Request for quotationCAS: 32908-73-9
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: Peptide 401 Visit Supplier Webpage Request for quotationCAS: 32908-73-9
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Product Name: Mast Cell Degranulating Peptide Visit Supplier Webpage Request for quotation
CAS: 32908-73-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 32908-73-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
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ACETIC ACID 100 % PURE PH. EUR., USP