340-05-6
1-Phenyl-2,2,2-trifluoroethanol
CAS: 340-05-6
Molecular Formula: C8H7F3O
340-05-6 - Names and Identifiers
| Name | 1-Phenyl-2,2,2-trifluoroethanol |
| Synonyms | 1-Phenyl-2,2,2-trifluoroethanol ALPHA-(TRIFLUOROMETHYL)BENZYL A (±)-Phenyl-2,2,2-trifluoroethanol alpha-(Trifluoromethyl)benzyl alcohol beta,beta,beta-Trifluoro-alpha-hydroxyethylbenzene 1-Phenyl-2,2,2-trifluoroethanol,a-Trifluoromethylbenzyl alcohol |
| CAS | 340-05-6 |
| EINECS | 206-429-1 |
| InChI | InChI=1/C8H7F3O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5,7,12H |
340-05-6 - Physico-chemical Properties
| Molecular Formula | C8H7F3O |
| Molar Mass | 176.14 |
| Density | 1.297g/mLat 20°C(lit.) |
| Melting Point | 74.3-75.2 °C |
| Boling Point | 64-65°C5mm Hg(lit.) |
| Flash Point | 184°F |
| Appearance | liquid |
| Specific Gravity | 1.293 |
| Color | Colorless to Brown |
| BRN | 3197623 |
| pKa | 11.91±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | n20/D 1.462 |
| MDL | MFCD00004498 |
340-05-6 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29062990 |
| Hazard Class | IRRITANT |
340-05-6 - Introduction
1-Phenyl-2,2,2-trifluoroethanol is an organic compound with the chemical formula C8H7F3O. It is a colorless liquid with a pungent, aromatic smell.
As a reaction reagent, 1-Phenyl-2,2,2-trifluoroethanol has a wide range of uses in organic synthesis. It can be used to catalyze substitution reactions of alcohols, such as addition reactions of olefins. In addition, it is a strongly acidic reagent that can be used in acid-catalyzed reactions, such as esterification reactions and acid-catalyzed carbon-carbon bond formation reactions.
There are many ways to prepare 1-Phenyl-2,2,2-trifluoroethanol. One common method is by reacting fluoroethanol with phenyl bromide. It is first necessary to prepare sodium p-trifluorotoluene sulfonate (para-Trifluoromethanesulfonic acid sodium salt), and then react it with fluoroethanol under acidic conditions to obtain 1-Phenyl-2,2,2-trifluoroethanol.
Regarding safety information, 1-Phenyl-2,2,2-trifluoroethanol is an organic substance, and safety measures should be paid attention to when using it. It is a combustible substance and needs to be kept away from fire and high temperatures. In the process of use, should avoid contact with oxidants, strong bases and strong acids to prevent the occurrence of dangerous reactions. It is also recommended to wear suitable protective equipment, such as gloves and eye protection, to ensure safe use.
As a reaction reagent, 1-Phenyl-2,2,2-trifluoroethanol has a wide range of uses in organic synthesis. It can be used to catalyze substitution reactions of alcohols, such as addition reactions of olefins. In addition, it is a strongly acidic reagent that can be used in acid-catalyzed reactions, such as esterification reactions and acid-catalyzed carbon-carbon bond formation reactions.
There are many ways to prepare 1-Phenyl-2,2,2-trifluoroethanol. One common method is by reacting fluoroethanol with phenyl bromide. It is first necessary to prepare sodium p-trifluorotoluene sulfonate (para-Trifluoromethanesulfonic acid sodium salt), and then react it with fluoroethanol under acidic conditions to obtain 1-Phenyl-2,2,2-trifluoroethanol.
Regarding safety information, 1-Phenyl-2,2,2-trifluoroethanol is an organic substance, and safety measures should be paid attention to when using it. It is a combustible substance and needs to be kept away from fire and high temperatures. In the process of use, should avoid contact with oxidants, strong bases and strong acids to prevent the occurrence of dangerous reactions. It is also recommended to wear suitable protective equipment, such as gloves and eye protection, to ensure safe use.
Last Update：2024-04-10 22:29:15
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