34036-07-2
3,4-Difluorobenzaldehyde
CAS: 34036-07-2
Molecular Formula: C7H4F2O
34036-07-2 - Names and Identifiers
| Name | 3,4-Difluorobenzaldehyde |
| Synonyms | VHR CF DF 3,4-Difluorobenzalde 3,4-fluorobenzaldehyde 3,4-Difluorbenzaldehyd 3,4-Difluorbenzaldehyde 3,4-DIFLUOROBENZALDEHYDE 3,4-Difluorobenzaldehyde 3,4-Difluoro benzaldehyde 4-amino-2-fluorobutanoic acid 1,3-DiFluorobenzenebenzaldehyde |
| CAS | 34036-07-2 |
| EINECS | 422-180-3 |
| InChI | InChI=1/C4H8FNO2/c5-3(1-2-6)4(7)8/h3H,1-2,6H2,(H,7,8) |
34036-07-2 - Physico-chemical Properties
| Molecular Formula | C7H4F2O |
| Molar Mass | 142.1 |
| Density | 1.288 g/mL at 25 °C (lit.) |
| Boling Point | 53-55°C (15 mmHg) |
| Flash Point | 150°F |
| Solubility | 3.962g/l |
| Vapor Presure | 0.00559mmHg at 25°C |
| Appearance | Liquid |
| Specific Gravity | 1.288 |
| Color | Clear colorless to yellow |
| BRN | 2241231 |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Air Sensitive |
| Refractive Index | n20/D 1.5(lit.) |
| Physical and Chemical Properties | Boiling Point: 53 - 55 at 15mm Hg density: 1.292 flash point: 65 |
34036-07-2 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 2 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29124990 |
| Hazard Class | IRRITANT |
34036-07-2 - Reference Information
| brief introduction | 3, 4-difluorobenzaldehyde is a colorless and transparent liquid with a boiling point of 53-55 ℃ and a density of 1.288 g/ml. it is slightly soluble in hot alcohol and ether, insoluble in water, and can volatilize with water vapor. 3, 4-difluorobenzaldehyde is one of the important raw materials for the synthesis of fine chemicals, and is used for the synthesis of pesticides, pharmaceuticals and liquid crystal material intermediates. |
| use | 3, 4-difluorobenzaldehyde is used to synthesize fluoro-substituted analogs of curcumin as a therapeutic agent for anti-cancer and/or anti-cancer and/or drug-resistant cancer development. Medicine, pesticides, liquid crystal material intermediates. |
| application | 3, 4-difluorobenzaldehyde is the raw material of the new antiplatelet agglutination drug ticagrelor, which is developed by AstraZeneca (AstraZeneca) company in the United States Successfully developed, it is the world's first reversible oral P2Y12 adenosine diphosphate receptor antagonist. |
| prepare | 5L four-mouth bottle, mechanically stirring, nitrogen protection, adding magnesium strips, 400g tetrahydrofuran and iodine particles in turn, adding 41.7g of 2-chloropropane at normal temperature, initiating after 10min, with the highest temperature of 40 ℃, cooling, adding the prepared 2-chloropropane solution dropwise at 30-40 ℃, adding the solution dropwise for 4.5h, keeping the temperature for 1h, basically free of magnesium strips. Cooling, adding 3, 4-difluorobromobenzene solution (654g of 3, 4-difluorobromobenzene and 700g of tetrahydrofuran) dropwise at 0-10 ℃, and adding the solution dropwise in 50min. Heat preservation reaction can reach normal temperature. After the reaction is completed, the temperature is reduced, and DMF solution (291.3g DMF and 300g tetrahydrofuran) is added dropwise at 0-10 ℃ for 40min. The temperature is controlled below 10 ℃, 700g of water is added dropwise, then concentrated hydrochloric acid is added dropwise to adjust the pH to about 4, about 840g of hydrochloric acid is used for stratification, the lower aqueous phase is extracted twice with 500g of toluene, the organic layer is combined, 500g of saturated salt water is used for washing once, and then 500g of water is used for washing once. The 65 ℃ water pump is concentrated under reduced pressure to solvent-free to obtain crude product, which is distilled under reduced pressure to obtain pure product with purity above 99.5% and yield 86%. |
Last Update：2024-04-09 02:00:05
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