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34221-41-5

(2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one

CAS: 34221-41-5

Molecular Formula: C16H14O4

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34221-41-5 - Names and Identifiers

Name (2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
Synonyms ECHINATIN
Echinatin
34221-41-5
Retrochalcone
ECHINATIN(RG)(CALL)
4'-Dihydroxy-2-Methoxychalcone
4,4'-Dihydroxy-2-Methoxychalcone
(E)-4,4'-Dihydroxy-2-methoxychalcone
4,4'-Dihydroxy-2-methoxy-trans-chalcone
(E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
(E)-3-(4-Hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
(2E)-3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
2-Propen-1-one, 3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-,(2E)-
2-propen-1-one, 3-(4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
CAS 34221-41-5
InChI InChI=1/C16H14O4/c1-20-16-10-14(18)8-4-12(16)5-9-15(19)11-2-6-13(17)7-3-11/h2-10,17-18H,1H3/b9-5+

34221-41-5 - Physico-chemical Properties

Molecular FormulaC16H14O4
Molar Mass270.28
Density1.282±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point210°C (dec.)
Boling Point509.8±50.0 °C(Predicted)
Flash Point193.3°C
Solubility Soluble in methanol, ethanol, DMSO and other organic solvents
Vapor Presure5.16E-11mmHg at 25°C
AppearanceWhite crystalline powder
pKa7.82±0.15(Predicted)
Storage Condition2-8°C
Refractive Index1.657
MDLMFCD00075719
Physical and Chemical PropertiesWhite crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from licorice root.

34221-41-5 - Reference

Reference
Show more
1. Luo Yanyan, Liu Xiaoshuan, Wang Hongli, et al. Study on the purification process of total flavonoids from licorice residue by chemical transformation method [J]. Shaanxi Journal of Traditional Chinese Medicine, 2019, 040(010):1471-1476.
2. Cai Shuhui, Zhao huachong, Jia Meng, Zhao Xiaoli, Chi Yumei, Zhang Wen, Wang Honglan, Di Liuqing. Quality Evaluation of roasted licorice based on HPLC fingerprint and multi-component quantitative analysis [J]. Chinese Journal of Traditional Chinese Medicine, 2021,46(01):118-124.
3. Chang Guanhua, thin Yingyi, Cui Jie, Xu Lulu, Zhao Ziyan, Wang Wenquan, Hou Junling. Analysis of the main chemical components of the aerial parts of licorice based on UPLC-Q-Exactive Orbitrap-MS [J]. Chinese Journal of Traditional Chinese Medicine, 2021,46(06):1449-1459.
4. Luo, Hui-Long, et al. "A systematic quality control method of Huang Qi detection: simultaneous determination of eleven flavonoids and seven triterpenoid saponins by UHPLC-MS." Analytical Methods 6.13 (2014): 4593-4601.
5. [IF = 2.896] Tian-Ming Wang et al."Simultaneous determination of 14 major components in Longhu Rendan pills by ultra-high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry."Anal Methods-Uk. 2014 Apr;6(9):2923-2929
6. [IF=2.896] Hui-Long Luo et al."A systematic quality control method of Huangqi decoction: simultaneous determination of eleven flavonoids and seven triterpenoid saponins by UHPLC-MS."Anal Methods-Uk. 2014 Jun;6(13):4593-4601
7. [IF=6.15] Zhang Feng et al."Inhibition of drug-metabolizing enzymes by Jingyin granules: implications of herb-drug interactions in antiviral therapy."Acta Pharmacol Sin. 2021 Jun;:1-10
8. [IF=4.451] Zijian Wang et al."Licorice flavonoids nanoparticles prepared by liquid antisolvent re-crystallization exhibit higher oral bioavailability and antioxidant activity in rat."J Funct Foods. 2019 Jun;57:190

34221-41-5 - Reference Information

Plant source: Licorice
biological activity Echinatin is isolated from the Chinese herbal medicine licorice, chalcone, which has liver-protecting and anti-inflammatory effects. The Echinatin causes antioxidation through electron transfer (ET) and proton transfer (PT) in aqueous solution. In rats, Echinatin can be quickly absorbed and eliminated and widely distributed, with an absolute bioavailability of about 6.81%.
uses prickly licorice chalcone has anti-tumor, liver-protecting and anti-inflammatory effects.
used for content determination/identification/pharmacological experiment, etc.
Last Update:2024-04-09 20:45:29
34221-41-5
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