34252-44-3
2-methyl-2H-indazole-3-carboxylic acid
CAS: 34252-44-3
Molecular Formula: C9H8N2O2
34252-44-3 - Names and Identifiers
| Name | 2-methyl-2H-indazole-3-carboxylic acid |
| Synonyms | Granisetron EP impurity G 3-Carboxy-2-methyl-2H-indazole 2-Methylindazole-3-carboxylic acid 2-methyl-2H-indazole-3-carboxylic acid 2-METHYL-2H-INDAZOLE-3-CARBOXYLIC ACID 2H-Indazole-3-carboxylic acid,2-methyl- 2-Methylindazole-3-carboxylic acid 2-Methyl-2H-indazole-3-carboxylic acid |
| CAS | 34252-44-3 |
| EINECS | 691-338-3 |
| InChI | InChI=1/C9H8N2O2/c1-11-8(9(12)13)6-4-2-3-5-7(6)10-11/h2-5H,1H3,(H,12,13) |
34252-44-3 - Physico-chemical Properties
| Molecular Formula | C9H8N2O2 |
| Molar Mass | 176.17 |
| Density | 1.35 |
| Melting Point | 217-219 |
| Boling Point | 417.4±18.0 °C(Predicted) |
| Flash Point | 206.2°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.03E-07mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 3.02±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.653 |
34252-44-3 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| UN IDs | 2811 |
| HS Code | 29339900 |
| Hazard Note | Harmful |
34252-44-3 - Introduction
Acid (acid) is an organic compound whose chemical formula is C9H8N2O2.
Nature:
-Appearance: White or off-white crystalline solid;
-melting point: about 180-182°C;
-Solubility: Low solubility in water, more soluble in organic solvents such as ethanol and dichloromethane.
Use:
acid has certain applications in the field of drug synthesis:
-It can be used as a potential active molecular skeleton for the design and synthesis of biologically active compounds;
-With antibacterial and anti-inflammatory properties, it can be used as a drug intermediate for the synthesis of antibiotics, anti-inflammatory drugs, etc.
Preparation Method:
The preparation of acrylic is generally carried out by the following methods:
-Firstly, indole-3-bromoacetic acid was synthesized by esterification with indole and bromoacetic acid as raw materials;
-Then acetic acid is converted into its esterified derivative through reaction to obtain 2-methyl-2H-azole-3-acetic acid (ester);
-Finally, 2-methyl-2H-indazole-3-acetic acid is converted into acid by acid hydrolysis or alkali hydrolysis.
Safety Information:
Due to the lack of sufficient safety data, the use of acid may have certain risks. In laboratory and industrial production, appropriate safety and control measures must be taken to avoid contact with skin, eyes and inhalation of dust or gas. Appropriate personal protective equipment such as lab gloves, goggles and protective masks should be worn during use.
Before using or handling acid, you should refer to the relevant safety data sheet and chemical safety manual for more detailed and specific safety information and operating recommendations.
Nature:
-Appearance: White or off-white crystalline solid;
-melting point: about 180-182°C;
-Solubility: Low solubility in water, more soluble in organic solvents such as ethanol and dichloromethane.
Use:
acid has certain applications in the field of drug synthesis:
-It can be used as a potential active molecular skeleton for the design and synthesis of biologically active compounds;
-With antibacterial and anti-inflammatory properties, it can be used as a drug intermediate for the synthesis of antibiotics, anti-inflammatory drugs, etc.
Preparation Method:
The preparation of acrylic is generally carried out by the following methods:
-Firstly, indole-3-bromoacetic acid was synthesized by esterification with indole and bromoacetic acid as raw materials;
-Then acetic acid is converted into its esterified derivative through reaction to obtain 2-methyl-2H-azole-3-acetic acid (ester);
-Finally, 2-methyl-2H-indazole-3-acetic acid is converted into acid by acid hydrolysis or alkali hydrolysis.
Safety Information:
Due to the lack of sufficient safety data, the use of acid may have certain risks. In laboratory and industrial production, appropriate safety and control measures must be taken to avoid contact with skin, eyes and inhalation of dust or gas. Appropriate personal protective equipment such as lab gloves, goggles and protective masks should be worn during use.
Before using or handling acid, you should refer to the relevant safety data sheet and chemical safety manual for more detailed and specific safety information and operating recommendations.
Last Update：2024-04-09 21:04:16
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