3430-19-1
5-Methyl-pyridin-3-ylamine
CAS: 3430-19-1
Molecular Formula: C6H8N2
3430-19-1 - Names and Identifiers
| Name | 5-Methyl-pyridin-3-ylamine |
| Synonyms | 3-AMINO-5-PICOLINE 5-Methylpyridin-3-amin 5-Methylpyridin-3-amine 5-Methyl-3-pyridinamine 3-AMINO-5-METHYLPYRIDINE 5-Amino-3-methylpyridine 3-Pyridinamine, 5-methyl- 5-METHYL-PYRIDIN-3-YLAMINE 5-Methyl-pyridin-3-ylamine 3-Pyridinamine,5-methyl-(9CI) 5-methyl-3-pyridylamine hydrochloride salt |
| CAS | 3430-19-1 |
| EINECS | 624-420-4 |
| InChI | InChI=1/C6H8N2/c1-5-2-6(7)4-8-3-5/h2-4H,7H2,1H3 |
3430-19-1 - Physico-chemical Properties
| Molecular Formula | C6H8N2 |
| Molar Mass | 108.14 |
| Density | 1.068±0.06 g/cm3(Predicted) |
| Melting Point | 59-63 °C |
| Boling Point | 153°C |
| Flash Point | 135.6°C |
| Vapor Presure | 0.0118mmHg at 25°C |
| Appearance | Solid |
| pKa | 6.46±0.20(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.574 |
| MDL | MFCD04112508 |
3430-19-1 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| UN IDs | 2811 |
| WGK Germany | 3 |
| Hazard Note | Toxic |
| Hazard Class | IRRITANT, TOXIC |
| Packing Group | III |
3430-19-1 - Reference Information
| introduction | 3-amino -5-methylpyridine is a pyridine derivative. Pyridine and its derivatives are widely distributed in nature. Many plant components, such as alkaloids, contain pyridine ring compounds in their structures. They are the basis for the production of many important compounds and are indispensable raw materials in the production of medicines, pesticides, dyes, surfactants, rubber additives, feed additives, food additives, adhesives, etc. |
| use | 3-bromo -5-methylpyridine is an important intermediate in organic synthesis, mainly used in pharmaceutical intermediates, organic synthesis, organic solvents, and can also be used in dye production, pesticide production and perfume production. |
| preparation | diethyl malonate reacts with sodium to form a salt, then drops the toluene solution of 3-nitro-5-chloropyridine for condensation and anti-reaction , and then decarboxylation under acidic conditions to obtain 3-nitro-5-methylpyridine; the molar ratio of diethyl malonate, alkali metal and 3-nitro-5 chloropyridine is 6:1.3:1; 3-nitro-5-methylpyridine is catalyzed by Pd/C, methanol is used as solvent, hydrogenation reduction, suction filtration and filtrate concentration to obtain 3-amino-5-methylpyridine. |
Last Update：2024-04-09 21:54:55
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