346-34-9
4-fluoroindoline-2,3-dione
CAS: 346-34-9
Molecular Formula: C8H4FNO2
346-34-9 - Names and Identifiers
| Name | 4-fluoroindoline-2,3-dione |
| Synonyms | 4-Fluoroisatin 4-FLUOROINDOLINC-2,3-DIONC 4-FLUOROINDOLINE-2,3-DIONE 4-fluoroindoline-2,3-dione 4-Fluoro-1H-indole-2,3-dione 1H-Indole-2,3-dione,4-fluoro- 1H-indole-2,3-dione, 4-fluoro- 4-fluoro-2,3-dihydro-1H-indole-2,3-dione |
| CAS | 346-34-9 |
| EINECS | 1533716-785-6 |
| InChI | InChI=1/C8H4FNO2/c9-4-2-1-3-5-6(4)7(11)8(12)10-5/h1-3H,(H,10,11,12) |
346-34-9 - Physico-chemical Properties
| Molecular Formula | C8H4FNO2 |
| Molar Mass | 165.12 |
| Density | 1.477 |
| pKa | 8.56±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.584 |
346-34-9 - Reference Information
| application | 4-fluoro-2, 3-indoledione can be used as an intermediate in organic synthesis and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical generation process. |
| preparation | 600g concentrated sulfuric acid is added into a 1L reaction bottle equipped with a strong stirrer. after warming to 50 ℃, isonitroso acetylfluoroaniline (75g,0. 46mol) is added. at the same time, full stirring is carried out, indirect cooling is carried out with cold water, and the temperature is controlled at 60~75 ℃, when the isonitroso acetyl-fluoroaniline is added, the solution is heated to 80 ℃ and kept 60min,[TLC tracking, developing agent: V (n-hexane):V (ethyl acetate) = 2:1] The reaction is complete, then the reaction mixture is cooled to room temperature, added to crushed ice with 3 -4 times the volume of reactants, stirred for 0.5 h and filtered under reduced pressure, wash several times with cold water until neutral. Dissolve the obtained filter cake in 10% sodium hydroxide solution (250g) until it is alkaline. after decolorization with activated carbon, acidify with hydrochloric acid to pH3 ~ 4, precipitate orange crystals, cool and place 24h, filter, wash with water until neutral, and dry to obtain 4-fluorine -2,3-indoledione (60. 5g,0. 41mol) with a yield of 89.5%, mp:198 ℃ ~ 201 ℃. |
Last Update：2024-04-09 21:48:26
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