351-38-2
N-Chloroacetyl-3-(trifluoromethyl)aniline
CAS: 351-38-2
Molecular Formula: C9H7ClF3NO
351-38-2 - Names and Identifiers
| Name | N-Chloroacetyl-3-(trifluoromethyl)aniline |
| Synonyms | ASISCHEM P35096 ART-CHEM-BB B015650 TIMTEC-BB SBB003231 2-CHLORO-3'-(TRIFLUOROMETHYL)ACETANILIDE N-Chloroacetyl-3-(trifluoromethyl)aniline N-(CHLOROACETYL)-3-(TRIFLUOROMETHYL)ANILINE 2-CHLORO-N-[3-(TRIFLUOROMETHYL)PHENYL]ACETAMIDE N1-[3-(TRIFLUOROMETHYL)PHENYL]-2-CHLOROACETAMIDE |
| CAS | 351-38-2 |
| InChI | InChI=1/C9H7ClF3NO/c10-5-8(15)14-7-3-1-2-6(4-7)9(11,12)13/h1-4H,5H2,(H,14,15) |
351-38-2 - Physico-chemical Properties
| Molecular Formula | C9H7ClF3NO |
| Molar Mass | 237.61 |
| Density | 1.419±0.06 g/cm3(Predicted) |
| Melting Point | 62,5-64°C |
| Boling Point | 326.4±42.0 °C(Predicted) |
| Flash Point | 151.2°C |
| Vapor Presure | 0.000216mmHg at 25°C |
| pKa | 12.35±0.70(Predicted) |
| Storage Condition | Room Temprature |
| Refractive Index | 1.513 |
351-38-2 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Class | IRRITANT |
351-38-2 - Introduction
N-Chloroacetyl-3-(trifluoromethyl)aniline is an organic compound. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: Colorless to light yellow crystalline or powdery solid.
-Solubility: Soluble in organic solvents such as ethanol, chloroform and acetone, insoluble in water.
-Molecular formula: C9H7ClF3NO.
-Molecular weight: 239.61.
-Melting point: 62-63 ℃.
Use:
- N-Chloroacetyl-3-(trifluoromethyl)aniline is often used as an important intermediate in organic synthesis and has a wide range of applications.
-It can be used as an intermediate for certain drugs in the pharmaceutical field, such as anti-cancer drugs.
-It can also be used for the synthesis of pesticides.
Preparation Method:
The preparation of the N-Chloroacetyl-3-(trifluoromethyl)aniline can be completed by the following steps:
1. Dissolve aniline in dichloromethane.
2. Add N-chloroacetoimine and control the temperature below room temperature.
3. Reaction for several hours, then saturated aqueous hydrogen chloride solution is added.
4. Adjust the pH to basic with saturated sodium hydroxide solution and extract the product from the organic phase.
5. Finally, the target product is obtained by crystallization or purification process.
Safety Information:
- N-Chloroacetyl-3-(trifluoromethyl)aniline is an organic substance with certain toxicity.
-During operation, protective gloves, protective glasses and protective masks must be worn to avoid direct contact and inhalation.
-When storing and handling, keep away from ignition and oxidizing agents.
Nature:
-Appearance: Colorless to light yellow crystalline or powdery solid.
-Solubility: Soluble in organic solvents such as ethanol, chloroform and acetone, insoluble in water.
-Molecular formula: C9H7ClF3NO.
-Molecular weight: 239.61.
-Melting point: 62-63 ℃.
Use:
- N-Chloroacetyl-3-(trifluoromethyl)aniline is often used as an important intermediate in organic synthesis and has a wide range of applications.
-It can be used as an intermediate for certain drugs in the pharmaceutical field, such as anti-cancer drugs.
-It can also be used for the synthesis of pesticides.
Preparation Method:
The preparation of the N-Chloroacetyl-3-(trifluoromethyl)aniline can be completed by the following steps:
1. Dissolve aniline in dichloromethane.
2. Add N-chloroacetoimine and control the temperature below room temperature.
3. Reaction for several hours, then saturated aqueous hydrogen chloride solution is added.
4. Adjust the pH to basic with saturated sodium hydroxide solution and extract the product from the organic phase.
5. Finally, the target product is obtained by crystallization or purification process.
Safety Information:
- N-Chloroacetyl-3-(trifluoromethyl)aniline is an organic substance with certain toxicity.
-During operation, protective gloves, protective glasses and protective masks must be worn to avoid direct contact and inhalation.
-When storing and handling, keep away from ignition and oxidizing agents.
Last Update：2024-04-09 02:00:45
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Spot supply
Product Name: 2-Chloro-N-(3-(trifluoromethyl)phenyl)acetamide Request for quotationCAS: 351-38-2
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Product Name: N-(CHLOROACETYL)-3-(TRIFLUOROMETHYL)ANILINE Visit Supplier Webpage Request for quotation
CAS: 351-38-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 351-38-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
351-38-2
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