352535-82-1
(3-chloro-2-fluorophenyl)boronic acid
CAS: 352535-82-1
Molecular Formula: C6H5BClFO2
352535-82-1 - Names and Identifiers
352535-82-1 - Physico-chemical Properties
| Molecular Formula | C6H5BClFO2 |
| Molar Mass | 174.37 |
| Density | 1.41±0.1 g/cm3(Predicted) |
| Melting Point | 223°C (dec.)(lit.) |
| Boling Point | 315.1±52.0 °C(Predicted) |
| Flash Point | 144.4°C |
| Water Solubility | Insoluble in water. Soluble in organic solvents. |
| Vapor Presure | 0.000188mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| pKa | 7.35±0.58(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.533 |
352535-82-1 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| WGK Germany | 3 |
| Hazard Note | Irritant/Keep Cold |
352535-82-1 - Introduction
(3-chroo-2-fluorophenyl) boronic acid is an organic compound with the chemical formula C6H5BClF. The following is a description of its nature, use, formulation and safety information:
Nature:
(3-chloro-2-fluorophenyl)boronic acid is a white solid that is soluble in many organic solvents at room temperature, such as ethanol, dimethyl sulfoxide and dichloromethane. It is sensitive to air and moisture and should be stored in a dry environment.
Use:
(3-choro-2-fluorophenyl) boronic acid is widely used as an important intermediate in organic synthesis. It can be used as a reagent for the synthesis of derivatives of aromatic compounds and the transformation of functional groups. It participates in many reactions, such as Suzuki coupling reaction and C- H functionalization reaction, and can be used to prepare raw materials for drugs, pesticides, cosmetics, etc.
Preparation Method:
(3-chloro-2-fluorophenyl)boronic acid is usually prepared by reacting 3-chloro-2-fluorophenyl methanol with boric acid. The reaction is generally carried out in an organic solvent under neutral or basic conditions, and the desired product is obtained by controlling the reaction time and reaction conditions.
Safety Information:
Appropriate safety measures should be taken when handling (3-chloro-2-fluorophenyl)boronic acid. It may be irritating to the eyes, skin, and respiratory tract, and may be toxic to aquatic organisms. Wear appropriate protective equipment such as chemical protective gloves, goggles and protective masks during use. If skin contact or inhalation occurs, rinse immediately with water and seek medical attention. During use and storage, keep well ventilated and away from fire and flammable materials. Use the compound in accordance with relevant regulations and operating guidelines.
Nature:
(3-chloro-2-fluorophenyl)boronic acid is a white solid that is soluble in many organic solvents at room temperature, such as ethanol, dimethyl sulfoxide and dichloromethane. It is sensitive to air and moisture and should be stored in a dry environment.
Use:
(3-choro-2-fluorophenyl) boronic acid is widely used as an important intermediate in organic synthesis. It can be used as a reagent for the synthesis of derivatives of aromatic compounds and the transformation of functional groups. It participates in many reactions, such as Suzuki coupling reaction and C- H functionalization reaction, and can be used to prepare raw materials for drugs, pesticides, cosmetics, etc.
Preparation Method:
(3-chloro-2-fluorophenyl)boronic acid is usually prepared by reacting 3-chloro-2-fluorophenyl methanol with boric acid. The reaction is generally carried out in an organic solvent under neutral or basic conditions, and the desired product is obtained by controlling the reaction time and reaction conditions.
Safety Information:
Appropriate safety measures should be taken when handling (3-chloro-2-fluorophenyl)boronic acid. It may be irritating to the eyes, skin, and respiratory tract, and may be toxic to aquatic organisms. Wear appropriate protective equipment such as chemical protective gloves, goggles and protective masks during use. If skin contact or inhalation occurs, rinse immediately with water and seek medical attention. During use and storage, keep well ventilated and away from fire and flammable materials. Use the compound in accordance with relevant regulations and operating guidelines.
Last Update：2024-04-09 02:00:45
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