368-78-5
[3-(trifluoromethyl)phenyl]hydrazine
CAS: 368-78-5
Molecular Formula: C7H7F3N2
368-78-5 - Names and Identifiers
| Name | [3-(trifluoromethyl)phenyl]hydrazine |
| Synonyms | AKOS B028818 à,à,à-trifluoro-m-tolylhydrazine M-TRIFLUOROMETHYLPHENYL HYDRAZINE 3-(TRIFLUOROMETHYL)PHENYLHYDRAZINE 3-(trifluoromethyl)phenylhydrazine [3-(trifluoromethyl)phenyl]hydrazine (3-(Trifluoromethyl)phenyl)hydrazine 3-(trifluoromethyl)benzaldehyde oxime Hydrazine,[3-(trifluoromethyl)phenyl]- 1-[3-(TRIFLUOROMETHYL)PHENYL]HYDRAZINE |
| CAS | 368-78-5 |
| EINECS | 206-713-5 |
| InChI | InChI=1/C8H6F3NO/c9-8(10,11)7-3-1-2-6(4-7)5-12-13/h1-5,13H/b12-5- |
368-78-5 - Physico-chemical Properties
| Molecular Formula | C7H7F3N2 |
| Molar Mass | 176.14 |
| Density | 1.348g/mLat 25°C(lit.) |
| Boling Point | 80-83°C9mm Hg(lit.) |
| Flash Point | 225°F |
| Water Solubility | Not miscible or difficult to mix with water. |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.0975mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear yellow to orange to brown |
| BRN | 640075 |
| pKa | 4?+-.0.10(Predicted) |
| Storage Condition | Refrigerator, under inert atmosphere |
| Refractive Index | n20/D 1.504(lit.) |
368-78-5 - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| UN IDs | 2810 |
| WGK Germany | 3 |
| HS Code | 29280090 |
| Hazard Note | Irritant |
| Hazard Class | IRRITANT, IRRITANT-H |
368-78-5 - Introduction
[3-(trifluoromethyl)phenyl]hydrazine is an organic compound with the chemical formula C7H6F3N2. It has the form of a white crystalline solid with a high melting and boiling point. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: White crystalline solid
-Melting point: about 80-82 degrees Celsius
-Boiling point: about 245 degrees Celsius
-Solubility: Soluble in organic solvents such as ethanol, dichloromethane and ethyl acetate
-Stability: Stable at room temperature, but need to be protected from light
Use:
-Reagent in chemical reactions:[3-(trifluoromethyl)phenyl]hydrazine can be used as a reducing agent in organic synthesis reactions to reduce functional groups such as ketones, aldehydes and enols.
-Pharmaceutical field: Due to its selective reduction of key functional groups such as keto alcohols,[3-(trifluoromethyl)phenyl]hydrazine have certain application potential in drug synthesis.
Preparation Method:
[3-(trifluoromethyl)phenyl]hydrazine are mainly prepared by the following methods:
-Reaction 1: 3-chloromethylaniline is obtained by reacting with trifluoroacetic acid under the catalysis of a base.
C6H4ClN CF3COOH NaOH → C6H6FN2 NaCl H2O
-Reaction 2: 3-fluoromethylaniline is obtained by reacting with anhydrous ammonia.
C6H4F-NH2 NH3 → C6H6FN2 H2O
Safety Information:
[3-(trifluoromethyl)phenyl]hydrazine is an organic compound and should be used with the following safety precautions:
-Avoid contact with skin, eyes and respiratory tract, wear protective gloves, safety glasses and masks.
-Operate in a well-ventilated place to avoid inhaling odors.
-Store away from sunlight and isolated from incompatible substances.
-In case of accidental splashing and skin or inhalation, rinse immediately with plenty of water and seek medical attention.
Nature:
-Appearance: White crystalline solid
-Melting point: about 80-82 degrees Celsius
-Boiling point: about 245 degrees Celsius
-Solubility: Soluble in organic solvents such as ethanol, dichloromethane and ethyl acetate
-Stability: Stable at room temperature, but need to be protected from light
Use:
-Reagent in chemical reactions:[3-(trifluoromethyl)phenyl]hydrazine can be used as a reducing agent in organic synthesis reactions to reduce functional groups such as ketones, aldehydes and enols.
-Pharmaceutical field: Due to its selective reduction of key functional groups such as keto alcohols,[3-(trifluoromethyl)phenyl]hydrazine have certain application potential in drug synthesis.
Preparation Method:
[3-(trifluoromethyl)phenyl]hydrazine are mainly prepared by the following methods:
-Reaction 1: 3-chloromethylaniline is obtained by reacting with trifluoroacetic acid under the catalysis of a base.
C6H4ClN CF3COOH NaOH → C6H6FN2 NaCl H2O
-Reaction 2: 3-fluoromethylaniline is obtained by reacting with anhydrous ammonia.
C6H4F-NH2 NH3 → C6H6FN2 H2O
Safety Information:
[3-(trifluoromethyl)phenyl]hydrazine is an organic compound and should be used with the following safety precautions:
-Avoid contact with skin, eyes and respiratory tract, wear protective gloves, safety glasses and masks.
-Operate in a well-ventilated place to avoid inhaling odors.
-Store away from sunlight and isolated from incompatible substances.
-In case of accidental splashing and skin or inhalation, rinse immediately with plenty of water and seek medical attention.
Last Update：2024-04-09 02:00:46
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