374064-01-4
5-pyridin-3-yl-4H-pyrazole-3-carboxylic acid
CAS: 374064-01-4
Molecular Formula: C9H7N3O2
374064-01-4 - Names and Identifiers
374064-01-4 - Physico-chemical Properties
| Molecular Formula | C9H7N3O2 |
| Molar Mass | 189.17 |
| Density | 1.432 |
| Melting Point | 308-310℃ (DEC.) |
| Boling Point | 541.4±40.0 °C(Predicted) |
| Flash Point | 194.7°C |
| Vapor Presure | 4.66E-07mmHg at 25°C |
| pKa | 3.56±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.697 |
374064-01-4 - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. |
| HS Code | 29331990 |
| Hazard Class | IRRITANT |
374064-01-4 - Introduction
Acid is an organic compound with the chemical formula CFFFFFH NFO2.
Its properties include:
-Appearance: White crystal powder
-Melting point: 200-204°C
-Solubility: Soluble in some organic solvents such as chloroform and dimethyl sulfoxide, insoluble in water
the acid is commonly used in drug research and synthesis. It can be used as a pharmaceutical intermediate for the synthesis of anti-inflammatory, anti-tumor and other bioactive compounds. In addition, it is also used in the preparation of pyrazole heterocyclic compounds.
The method of preparing calcium acid usually includes the following steps:
(1) first reacting pyridine with ethylidene amine to obtain pyridine-3-vinylamine;
(2) reacting the product obtained in step (1) with propanedione in acetic acid to form a pyrazole derivative;
(3) Finally, the acidolysis reaction is carried out with acid to obtain acid.
Regarding safety information, this compound has no special safety risk report under routine operation. However, as a laboratory chemical, general laboratory safety practices should be followed, such as wearing appropriate personal protective equipment (such as gloves, goggles), avoiding contact with skin and eyes, avoiding inhalation of aerosols, and operating in a well-ventilated environment. If accidental contact occurs, rinse immediately with plenty of water and seek medical assistance if necessary.
Its properties include:
-Appearance: White crystal powder
-Melting point: 200-204°C
-Solubility: Soluble in some organic solvents such as chloroform and dimethyl sulfoxide, insoluble in water
the acid is commonly used in drug research and synthesis. It can be used as a pharmaceutical intermediate for the synthesis of anti-inflammatory, anti-tumor and other bioactive compounds. In addition, it is also used in the preparation of pyrazole heterocyclic compounds.
The method of preparing calcium acid usually includes the following steps:
(1) first reacting pyridine with ethylidene amine to obtain pyridine-3-vinylamine;
(2) reacting the product obtained in step (1) with propanedione in acetic acid to form a pyrazole derivative;
(3) Finally, the acidolysis reaction is carried out with acid to obtain acid.
Regarding safety information, this compound has no special safety risk report under routine operation. However, as a laboratory chemical, general laboratory safety practices should be followed, such as wearing appropriate personal protective equipment (such as gloves, goggles), avoiding contact with skin and eyes, avoiding inhalation of aerosols, and operating in a well-ventilated environment. If accidental contact occurs, rinse immediately with plenty of water and seek medical assistance if necessary.
Last Update：2024-04-09 20:52:54
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