3785-24-8
1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethanone
CAS: 3785-24-8
Molecular Formula: C13H12O3
3785-24-8 - Names and Identifiers
3785-24-8 - Physico-chemical Properties
| Molecular Formula | C13H12O3 |
| Molar Mass | 216.23 |
| Density | 1.285±0.06 g/cm3 (20 ºC 760 Torr) |
| Melting Point | 165-166℃ (methanol ) |
| Boling Point | 357.9±22.0 °C(Predicted) |
| Flash Point | 217.8°C |
| Solubility | Soluble in methanol, ethanol, ethyl acetate, insoluble in water |
| Vapor Presure | 2.05E-07mmHg at 25°C |
| Appearance | Pale yellow crystal |
| pKa | 5.13±0.50(Predicted) |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.668 |
| Physical and Chemical Properties | Light yellow crystal, soluble in methanol, ethanol, ethyl acetate, insoluble in water, derived from the roots of the Polygonaceae plant sheep's hoof or Nepalese sheep's hoof. |
| In vitro study | Nepodin (Musizin) exhibits significant IC 50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively. |
| In vivo study | Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner. Animal Model: C57BL/KsJ-db/db mice Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance. |
3785-24-8 - Reference Information
| biological activity | Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor, isolated from Rumex crispus. Nepodin (Musizin) stimulates the transport of GLUT4 to the plasma membrane by activating AMPK. Nepodin (Musizin) has anti-diabetic and anti-malarial effects. |
| in vitro study | Nepodin (Musizin) exhibits significant IC 50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively. |
| in vivo study | Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner. Animal Model: C57BL/KsJ-db/db mice Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance. |
| Animal Model: | C57BL/KsJ-db/db mice |
| Dosage: | 2 mg/kg; 10 mg/kg |
| Administration: | Orally administration; 2-10 mg/kg; 4 weeks |
| Result: | Had antihyperglycemic potential and improved insulin resistance. |
| Chemical properties | Light yellow crystals, soluble in methanol, ethanol, ethyl acetate, insoluble in water, derived from the roots of the Polygonaceae plant sheep's hoof or Nepalese sheep's hoof. |
Last Update：2024-04-09 20:49:11
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Multiple SpecificationsSpot supply
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Mobile: 609-228-6898
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