38186-88-8
2-Chloro-5-fluoronicotinic acid
CAS: 38186-88-8
Molecular Formula: C6H3ClFNO2
38186-88-8 - Names and Identifiers
38186-88-8 - Physico-chemical Properties
| Molecular Formula | C6H3ClFNO2 |
| Molar Mass | 175.54 |
| Density | 1.576±0.06 g/cm3(Predicted) |
| Melting Point | 141-142°C |
| Boling Point | 297.0±35.0 °C(Predicted) |
| Vapor Presure | 349mmHg at 25°C |
| Appearance | Crystallization |
| pKa | 1.67±0.25(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.313 |
| MDL | MFCD03092932 |
38186-88-8 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S7/9 - S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S38 - In case of insufficient ventilation, wear suitable respiratory equipment. S51 - Use only in well ventilated areas. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
38186-88-8 - Reference Information
| application | 2-chloro -5-fluoronicotinic acid has special chemical properties and medicinal activity. it is an intermediate of many medicines and pesticides and has a very broad application prospect. It can also be used as pharmaceutical and pharmaceutical intermediates, hair coloring aids, polymer stabilizers, antioxidants and anti-fog agents for photosensitive materials, etc. 2-chloro-5-fluorocinicotinic acid is also an intermediate of many high value-added drugs such as diabetes drugs, antidepressants, anti-tumor drugs, local anesthesia drugs, antihypertensive drugs, etc., and it is used in lowering blood pressure, anti-swelling, and anti-coccidiosis. And other medical fields have applications. |
| preparation | the synthesis steps of 2-chlorine -5-fluoronicotinic acid are as follows: degassing DMF(270 mL), Pd(OAc)2(0.05 eq,2.7g,11.9 mmol), PPh3(0.1 eq,6.2g), 23.8 mmol) and degassing Et3N(6 eq,200 mL,1428.6 mmol). Stir the mixture for 20 minutes, then add HCOOH(3 eq,28 mL,714.3 mmol), after 5 minutes add 2, 6-dichloro-5-fluoronicotinic acid (50g,238.1 mmol) and stir the mixture at 50°C. After the reaction, a processed aliquot sample was analyzed (1H NMR). When all starting materials are consumed (24 hours), cool the mixture to 0°C and add water (500 mL). After 20 minutes, the mixture is filtered through a piece of Celite pad rinsed with water. The mixture was alkalized to pH 9 with 30% aqueous sodium hydroxide and washed with EtOAc(2x). Hydrochloric acid (12 N) was slowly added to pH 1 and the solution was saturated with sodium chloride. The mixture was extracted with EtOAc(3x). The combined organic extract was washed with salt water, dried (Na2SO4) and concentrated under reduced pressure to obtain 37g(88%) of beige solid for the next step without further purification. 1H nuclear magnetic resonance (DMSO-d 6,300 MHz):δ8.16(dd,1H);8.58(d,1H). |
Last Update：2024-04-10 22:29:15
Supplier List
Featured ProductsSpot supply
Product Name: 2-Chloro-5-fluoronicotinic acid Visit Supplier Webpage Request for quotationCAS: 38186-88-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Chloro-5-fluoronicotinic acid Request for quotationCAS: 38186-88-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Chloro-5-fluoronicotinic acid Visit Supplier Webpage Request for quotationCAS: 38186-88-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-Chloro-5-Fluoronicotinic Visit Supplier Webpage Request for quotationCAS: 38186-88-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 2-Chloro-5-Fluoronicotinic Acid Visit Supplier Webpage Request for quotation
CAS: 38186-88-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 38186-88-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: 2-Chloro-5-fluoronicotinic acid Visit Supplier Webpage Request for quotationCAS: 38186-88-8
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 2-Chloro-5-fluoronicotinic acid Request for quotationCAS: 38186-88-8
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: 2-Chloro-5-fluoronicotinic acid Visit Supplier Webpage Request for quotationCAS: 38186-88-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: 2-Chloro-5-Fluoronicotinic Visit Supplier Webpage Request for quotationCAS: 38186-88-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 2-Chloro-5-Fluoronicotinic Acid Visit Supplier Webpage Request for quotation
CAS: 38186-88-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 38186-88-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History